Surgical Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
BMC Surg. 2023 Aug 11;23(1):230. doi: 10.1186/s12893-023-02126-z.
The spleen is a responsible significant part of the immune system; after Splenectomy following trauma, the immune system changes; splenic autotransplantation can preserve the immune system after trauma and Splenectomy.
Patients can be protected from immune dysfunction by autotransplanting splenic tissues after splenectomy following trauma because their immune systems and spleens are changed. Patients can gain their immune function after splenic autotransplantation.
Patient classification methods are into three categories, Group A, 6 cases with auto-translation; Group B, 6 cases without transplantation; Group C, seven regular people serving as the control.
The aim of the work is not to compare outcome methods or compare types of autotransplantation; This work aims to document postoperative radiological, immunological, clinical, and hematological investigations. We concentrated on the results of investigations more than the types of operation or approach or types of autotransplantation.
We showed that, after comparing each group with normal individuals subjects, patients who did not undergo autotransplantation had significantly higher platelet counts, a more significant percentage of micronucleated reticulocytes, increased levels of naive B lymphocytes, changes in class-switched memory and class-unswitched memory B cells, and higher levels of PD1 on CD8 + T lymphocytes. Nevertheless, neither splenic autotransplant patients nor the average general population showed any appreciable variations in any of the parameters.
Spleen's activities with adequate hemocatheter activity and recovery of the immunological deficit after splenic autotransplantation.
脾脏是免疫系统的重要组成部分；创伤后脾切除后，免疫系统会发生变化；脾自体移植可以在创伤和脾切除后保留免疫系统。
脾切除后，通过自体移植脾组织，患者可以免受免疫功能障碍的影响，因为他们的免疫系统和脾脏发生了变化。患者可以在脾自体移植后获得免疫功能。
患者分类方法分为三组，A 组，6 例自动移植；B 组，6 例未移植；C 组，7 例正常人作为对照。
本工作的目的不是比较结果方法或比较自体移植的类型；本工作旨在记录术后放射学、免疫学、临床和血液学调查。我们更关注调查结果，而不是手术或方法的类型或自体移植的类型。
我们表明，与正常个体相比，未进行自体移植的患者血小板计数明显升高，网织红细胞微核率明显升高，幼稚 B 淋巴细胞水平升高，类别转换记忆和类别未转换记忆 B 细胞发生变化，CD8+T 淋巴细胞上 PD1 水平升高。然而，脾自体移植患者和普通人群在任何参数上均未显示出任何明显变化。
脾的活动与足够的血液动力学活性和脾自体移植后免疫缺陷的恢复有关。
