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体外膜肺氧合(ECLS)中心的开端:罗马尼亚急诊科首例成功的体外心肺复苏(ECPR)——基于病例的回顾

The Beginning of an ECLS Center: First Successful ECPR in an Emergency Department in Romania-Case-Based Review.

作者信息

Nedelea Paul Lucian, Manolescu Emilian, Ciumanghel Adi-Ionut, Constantin Mihai, Hauta Alexandra, Sirbu Oana, Ionescu Lidia, Blaj Mihaela, Corlade-Andrei Mihaela, Sorodoc Victorita, Cimpoesu Diana

机构信息

Department of Emergency Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Emergency Department, "St. Spiridon" Emergency Clinical County Hospital, 700111 Iasi, Romania.

出版信息

J Clin Med. 2023 Jul 26;12(15):4922. doi: 10.3390/jcm12154922.

DOI:10.3390/jcm12154922
PMID:37568324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419366/
Abstract

According to the latest international resuscitation guidelines, extracorporeal cardiopulmonary resuscitation (ECPR) involves the utilization of extracorporeal membrane oxygenation (ECMO) in specific patients experiencing cardiac arrest, and it can be considered in situations where standard cardiopulmonary resuscitation efforts fail if they have a potentially reversible underlying cause, among which we can also find hypothermia. In cases of cardiac arrest, both witnessed and unwitnessed, hypothermic patients have higher chances of survival and favorable neurological outcomes compared to normothermic patients. ECPR is a multifaceted procedure that requires a proficient team, specialized equipment, and comprehensive multidisciplinary support within a healthcare system. However, it also carries the risk of severe, life-threatening complications. With the increasing use of ECPR in recent years and the growing number of centers implementing this technique outside the intensive care units, significant uncertainties persist in both prehospital and emergency department (ED) settings. Proper organization is crucial for an ECPR program in emergency settings, especially given the challenges and complexities of these treatments, which were previously not commonly used in ED. Therefore, within a narrative review, we have incorporated the initial case of ECPR in an ED in Romania, featuring a successful resuscitation in the context of severe hypothermia (20 °C) and a favorable neurological outcome (CPC score of 1).

摘要

根据最新的国际复苏指南,体外心肺复苏(ECPR)是指在特定心脏骤停患者中使用体外膜肺氧合(ECMO),对于有潜在可逆病因且标准心肺复苏失败的情况可考虑采用ECPR,其中也包括低温情况。在心脏骤停病例中,无论是否被目击,与体温正常的患者相比,低温患者存活及获得良好神经功能转归的几率更高。ECPR是一个多方面的过程,需要一个专业的团队、专门的设备以及医疗系统内全面的多学科支持。然而,它也存在严重的、危及生命的并发症风险。近年来,随着ECPR使用的增加以及越来越多的中心在重症监护病房之外实施这项技术,院前和急诊科环境中仍存在重大的不确定性。在紧急情况下,适当的组织对于ECPR项目至关重要,尤其是考虑到这些治疗的挑战和复杂性,而这些治疗以前在急诊科并不常用。因此,在一项叙述性综述中,我们纳入了罗马尼亚急诊科首例ECPR病例,该病例在严重低温(20°C)情况下成功复苏且神经功能转归良好(脑功能分类[CPC]评分为1)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c17/10419366/f2b683899e60/jcm-12-04922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c17/10419366/f2b683899e60/jcm-12-04922-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c17/10419366/f2b683899e60/jcm-12-04922-g001.jpg

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A systematic review and meta-analysis of anticoagulation practices and mortality in extracorporeal cardiopulmonary resuscitation.
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Extracorporeal cardiopulmonary resuscitation in adult patients with out-of-hospital cardiac arrest: a retrospective large cohort multicenter study in Japan.体外心肺复苏在院外心脏骤停的成年患者中的应用:日本一项回顾性大型队列多中心研究。
Crit Care. 2022 May 9;26(1):129. doi: 10.1186/s13054-022-03998-y.
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A Comparison between Conventional and Extracorporeal Cardiopulmonary Resuscitation in Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis.院外心脏骤停中传统心肺复苏与体外心肺复苏的比较:一项系统评价与荟萃分析
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