Wei Fengqin, Zhang Xinran, Yang Shengnan, Geng Jing, Xie Bingbing, Ren Yanhong, Dai Huaping
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing 100029, China.
National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, China.
J Clin Med. 2023 Jul 27;12(15):4926. doi: 10.3390/jcm12154926.
primary Sjögren's syndrome (pSS) is an autoimmune disease, of which the most common complication is interstitial lung disease (ILD). This study aimed to analyze the clinical value of Krebs von den Lungen-6 (KL-6), carcinoembryonic antigen (CEA), and carbohydrate antigen 153(CA153) in patients with pSS complicated with ILD (pSS-ILD), given that only few studies have evaluated this.
This is a cross-sectional study. Serum KL-6 levels (U/mL) were measured using chemiluminescence immunoassay, and concentrations of serum tumor markers were determined using the immunofluorescence method in 64 cases of pSS-ILD (pSS-ILD group), 23 cases without ILD (non-ILD group), and 45 healthy controls. The correlation between KL-6 and tumor markers as well as lung function was analyzed, and the factors that were associated with pSS-ILD were screened.
The serum KL-6 was more abnormally increased in patients with pSS-ILD, and the serum KL-6, CEA, carbohydrate antigen 125 (CA125), and CA153 levels were significantly higher in the pSS-ILD group than in the non-ILD and healthy control groups ( < 0.05). KL-6, CEA, and CA153 were negatively correlated with forced vital capacity (FVC%), forced expiratory volume in 1 s (FEV1%), total lung capacity (TLC%), and diffusing capacity for carbon monoxide (DLCO%) (all < 0.05). Multivariate logistic analysis showed that KL-6 was an independent factor associated with pSS-ILD.
In conclusion, we evaluated the association between clinical values of KL-6, tumor markers, and pSS-ILD, and found that KL-6 and tumor markers such as CEA, CA153, and CA125 in patients with pSS-ILD were higher than in patients with non-ILD, and KL-6 was more abnormally increased and significantly associated with ILD development in patients with pSS.
原发性干燥综合征（pSS）是一种自身免疫性疾病，其最常见的并发症是间质性肺疾病（ILD）。鉴于仅有少数研究对此进行评估，本研究旨在分析克雷伯氏肺糖蛋白-6（KL-6）、癌胚抗原（CEA）和糖类抗原153（CA153）在合并ILD的pSS患者（pSS-ILD）中的临床价值。
这是一项横断面研究。采用化学发光免疫分析法测定64例pSS-ILD患者（pSS-ILD组）、23例无ILD患者（非ILD组）和45例健康对照者血清KL-6水平（U/mL），采用免疫荧光法测定血清肿瘤标志物浓度。分析KL-6与肿瘤标志物以及肺功能之间的相关性，并筛选与pSS-ILD相关的因素。
pSS-ILD患者血清KL-6异常升高更为明显，pSS-ILD组血清KL-6、CEA、糖类抗原125（CA125）和CA153水平显著高于非ILD组和健康对照组（<0.05）。KL-6、CEA和CA153与用力肺活量（FVC%）、第1秒用力呼气量（FEV1%）、肺总量（TLC%）和一氧化碳弥散量（DLCO%）呈负相关（均<0.05）。多因素logistic分析显示，KL-6是与pSS-ILD相关的独立因素。
总之，我们评估了KL-6、肿瘤标志物的临床价值与pSS-ILD之间的关联，发现pSS-ILD患者的KL-6以及CEA、CA153和CA125等肿瘤标志物高于非ILD患者，且pSS患者中KL-6异常升高更为明显，与ILD的发生显著相关。
