Evers Charlotte, Böhringer Daniel, Kallee Sara, Keye Philip, Philippin Heiko, Piotrowski Timothy, Reinhard Thomas, Lübke Jan
Eye Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
International Centre for Eye Health, Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
J Clin Med. 2023 Jul 31;12(15):5043. doi: 10.3390/jcm12155043.
The XEN gel stent reduces intraocular pressure (IOP) in glaucoma. XEN-45 is widely used; the newer XEN-63 has a larger lumen targeting potentially lower IOP outcomes. We retrospectively compared the first 15 XEN-63 cases to 15 matched XEN-45 controls. With a preoperative IOP of 18.1 ± 3.9 mmHg (mean ± SD) and a final IOP of 9.1 ± 2.0 mmHg, XEN-63 implantation resulted in an IOP reduction of 44.6 ± 16.5%. Similarly, with a preoperative IOP of 18.3 ± 4.5 mmHg and a final IOP of 10.3 ± 2.1 mmHg, XEN-45 implantation resulted in an IOP reduction of 40.1 ± 17.2%. The median follow-up period was 204 days (range 78-338 days) for the XEN-63 group and 386 days (range 99-1688 days) for the XEN-45 group. In total, 5/15 eyes of each group underwent open conjunctival bleb revision within the period of observation. Three eyes of the XEN-63 group had secondary glaucoma surgery. One eye in the XEN-63 group and three eyes in the XEN-45 group required a restart of antiglaucomatous medication. In conclusion, both stents effectively lower IOP and medication. XEN-63 achieved a slightly lower IOP over a short follow-up. Complication and revision rates were similar.
XEN凝胶支架可降低青光眼患者的眼压（IOP）。XEN - 45被广泛使用；更新的XEN - 63有更大的管腔，目标是实现可能更低的眼压降低效果。我们回顾性地将首批15例XEN - 63病例与15例匹配的XEN - 45对照病例进行了比较。XEN - 63植入术后，术前眼压为18.1±3.9 mmHg（均值±标准差），最终眼压为9.1±2.0 mmHg，眼压降低了44.6±16.5%。同样，XEN - 45植入术后，术前眼压为18.3±4.5 mmHg，最终眼压为10.3±2.1 mmHg，眼压降低了40.1±17.2%。XEN - 63组的中位随访期为204天（范围78 - 338天），XEN - 45组为386天（范围99 - 1688天）。在观察期内，每组各有5/15只眼进行了开放性结膜滤泡修复术。XEN - 63组有3只眼进行了继发性青光眼手术。XEN - 63组有1只眼，XEN - 45组有3只眼需要重新开始使用抗青光眼药物。总之，两种支架均能有效降低眼压并减少用药。在短期随访中，XEN - 63的眼压降低幅度略低。并发症和修复率相似。
