Ayoub Mohamed, Lutsch Selina, Behnes Michael, Akin Muharrem, Schupp Tobias, Akin Ibrahim, Rudolph Volker, Westermann Dirk, Mashayekhi Kambis
Division of Cardiology and Angiology, Heart Center University of Bochum, 32545 Bad Oeynhausen, Germany.
Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
J Clin Med. 2023 Jul 31;12(15):5044. doi: 10.3390/jcm12155044.
Present research on the influence of gender on the treatment of coronary artery disease (CAD) and the outcome after percutaneous coronary intervention (PCI) is inconsistent. Sex differences in the presentation of CAD and the success after treatment have been described. We intend to compare the male and female sex in the procedure and the long-term outcome of Rotational Atherectomy (RA). A total of 597 consecutive patients (20.3% female and 79.7% male, mean age 75.3 ± 8.9 years vs. 72.7 ± 9 years, < 0.001) undergoing Rotational Atherectomy between 2015 and 2020 were enrolled in the analysis. Demographic and clinical data were registered. In-hospital, 1-year, and 3-year MACCEs (major adverse cardiac and cerebrovascular events) were calculated. Women presented more often with myocardial infarction (23.9% vs. 14.9%, = 0.017). The intervention was mainly performed via femoral access compared to radial access (65.4% vs. 33.6%, = 0.002). Women had a smaller diameter of the balloon predilatation compared to men (2.8 ± 0.5 mm vs. 3.15 ± 2.4 mm, < 0.05) and a smaller maximum diameter of the implanted stent (3.5 ± 1.2 mm vs. 4.10 ± 6.5 mm, = 0.01). In-hospital, 1-year-, and 3-year MACCEs did not differ between the sexes. After a multivariate analysis, no difference between men and women could be detected. In conclusion, this analysis shows differences between women and men in periprocedural characteristics but does not show any differences after RA regarding in-hospital, 1-year-, and 3-year MACCEs.
目前关于性别对冠状动脉疾病（CAD）治疗及经皮冠状动脉介入治疗（PCI）后结局影响的研究结果并不一致。已有研究描述了CAD表现及治疗后成功率方面的性别差异。我们旨在比较男性和女性在旋磨术（RA）操作及长期结局方面的情况。分析纳入了2015年至2020年间连续接受旋磨术的597例患者（女性占20.3%，男性占79.7%，平均年龄分别为75.3±8.9岁和72.7±9岁，P<0.001）。记录了人口统计学和临床数据。计算了住院期间、1年和3年的主要不良心脑血管事件（MACCEs）。女性更常表现为心肌梗死（23.9%对14.9%，P=0.017）。与经桡动脉途径相比，干预主要通过股动脉途径进行（65.4%对33.6%，P=0.002）。与男性相比，女性球囊预扩张直径较小（2.8±0.5mm对3.15±2.4mm，P<0.05），植入支架的最大直径也较小（3.5±1.2mm对4.10±6.5mm，P=0.01）。住院期间、1年和3年的MACCEs在性别之间无差异。多因素分析后，未发现男性和女性之间存在差异。总之，该分析显示了女性和男性在围手术期特征方面存在差异，但在RA术后住院期间、1年和3年的MACCEs方面未显示任何差异。
