Hsieh Chi-Chia, Fu Yi-Hsiu, Ku Nien-En, Hsia Chia-Chun, Hung Yu-Tung, Hsu Tzu-Ju, Chen Sung-Hsiung, Kuo Shu-Jui
Department of Education, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Department of Education, Taichung Veterans General Hospital, Taichung 407219, Taiwan.
J Clin Med. 2023 Aug 3;12(15):5102. doi: 10.3390/jcm12155102.
Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence ( < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2-3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients.
慢性胰腺炎（CP）可能引发全身炎症，从而潜在地增加患癌易感性。然而，CP与胰腺外癌症之间的联系仍未得到充分探索。利用2000年至2017年台湾国民健康保险数据库的数据，我们通过倾向评分匹配，将5394例CP患者与21576例非CP个体进行了比较。与非CP个体相比，CP患者表现出显著更高的癌症风险（女性调整后风险比（aHR）为1.32，男性为1.68）和累积发病率（<0.001）。CP与胰腺癌（aHR = 3.51）、肝癌（aHR = 1.62）、胃癌（aHR = 2.01）及其他癌症（aHR = 2.09）存在显著关联。就肝癌而言，无论性别，CP与无病毒性肝炎的患者显著相关（女性aHR = 2.01；男性aHR = 1.54）。在CP诊断后的第一年内未观察到显著的癌症发生情况。约一半的CP患者在2至3年内发生胰腺癌或肝癌，而男性CP患者的胃癌主要发生在诊断后的第五年左右。这些发现为CP患者的潜在癌症筛查计划提供了参考。
