Neri Benedetto, Mancone Roberto, Savino Luca, Schiavone Sara, Formica Vincenzo, Pizzi Francesca, Salvatori Silvia, Mossa Michelangela, Migliozzi Stefano, Fiorillo Mariasofia, Morelli Cristina, Moscardelli Alessandro, Lolli Elisabetta, Calabrese Emma, Sica Giuseppe S, Monteleone Giovanni, Biancone Livia
Gastroenterology Unit, Department of Systems Medicine, University "Tor Vergata" of Rome, 00133 Roma, Italy.
Pathology Unit, Department of Biomedicine and Prevention, University "Tor Vergata" of Rome, 00133 Roma, Italy.
Cancers (Basel). 2023 Jul 26;15(15):3803. doi: 10.3390/cancers15153803.
A higher frequency of mucinous and signet-ring cell colonic adenocarcinoma has been reported in inflammatory bowel disease (IBD). The primary aim was to investigate the frequency of mucinous and signet-ring cell colorectal adenocarcinoma in patients with IBD (Cases) versus age-matched non-IBD Controls. The secondary aims were to compare the characteristics of these two histotypes of colorectal cancer (CRC) in IBD patients vs. Controls and to search for specific risk factors in IBD. In a case-control study, all IBD patients with CRC diagnosed from 2000 to 2022 were enrolled and matched for age (1:2) with non-IBD Controls with CRC. The study population included 120 CRC patients (40 IBD, 80 Controls). In IBD, CRC included standard adenocarcinoma in 23 (57.5%) patients mucinous/signet-ring cell adenocarcinoma in 17 (42.5%) patients. The proportion of mucinous/signet-ring cell adenocarcinoma was higher in IBD than in Controls (17 [42.5%] vs. 18 [22.5%]; = 0.03). In rectal CRC, the proportion of mucinous/signet-ring cell adenocarcinoma was higher than standard adenocarcinoma in IBD (8 [47.1%] vs. 4 [17.4%]; = 0.04) but not in Controls (4 [22.2%] vs. 20 [32.2%]; = 0.59). In rectal CRC, the proportion of these two histotypes was higher in Cases than in Controls (8/12 [66.6%] vs. 4/24 [16.6%]; = 0.008), with no risk factors identified in IBD. CRC was more frequently represented by mucinous/signet-ring cell adenocarcinoma in IBD than in age-matched non-IBD Controls. In IBD, these two CRC histotypes were more frequent in the rectum.
已有报道称，炎症性肠病（IBD）患者中黏液性和印戒细胞型结肠腺癌的发生率较高。主要目的是调查IBD患者（病例组）与年龄匹配的非IBD对照组中黏液性和印戒细胞型结直肠癌的发生率。次要目的是比较IBD患者与对照组中这两种结直肠癌组织学类型的特征，并寻找IBD中的特定危险因素。在一项病例对照研究中，纳入了2000年至2022年诊断为结直肠癌的所有IBD患者，并与患有结直肠癌的非IBD对照组按年龄（1:2）进行匹配。研究人群包括120例结直肠癌患者（40例IBD患者，80例对照组）。在IBD患者中，结直肠癌包括23例（57.5%）标准腺癌患者和17例（42.5%）黏液性/印戒细胞腺癌患者。IBD中黏液性/印戒细胞腺癌的比例高于对照组（17例[42.5%]对18例[22.5%]；P = 0.03）。在直肠癌中，IBD患者黏液性/印戒细胞腺癌的比例高于标准腺癌（8例[47.1%]对4例[17.4%]；P = 0.04），但在对照组中并非如此（4例[22.2%]对20例[32.2%]；P = 0.59）。在直肠癌中，病例组这两种组织学类型的比例高于对照组（8/12[66.6%]对4/24[16.6%]；P = 0.008），且未在IBD中发现危险因素。与年龄匹配的非IBD对照组相比，IBD患者中黏液性/印戒细胞腺癌型结直肠癌更为常见。在IBD中，这两种结直肠癌组织学类型在直肠中更为常见。
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