Shankar Sidharth, Manjunath Shiva, Alqahtani Saad Mohammad, Ganji Kiran Kumar, Nagate Raghavendra Reddy, Ghokale Shankar T, Nagarajappa Anil Kumar, Javali Mukhatar Ahmed, Tikare Shreyas, Khader Mohasin Abdul
ECHS, Air Force Hospital, Gorakhpur 273014, India.
Department of Periodontics, Institute of Dental Sciences, Bareilly 243006, India.
Diagnostics (Basel). 2023 Jul 26;13(15):2483. doi: 10.3390/diagnostics13152483.
This study aimed to quantify serum C-reactive protein (CRP) values in periodontally healthy people and explore the relationship between serum CRP levels and chronic periodontitis, and the influence of scaling as well as root planing (SRP) on serum CRP levels. The study included 100 systemically healthy adults ( = 100; 50 males and 50 females) who were separated into two groups: Group A (control) = 50; periodontally healthy subjects and Group B (test) = 50; subjects with chronic periodontitis. The test group (group B) was further separated randomly into two groups: B1 ( = 25) and B2 ( = 25). The clinical parameters and serum CRP levels were measured only once in Group A and before SRP in Group B1 subjects. In Group B2 subjects the clinical parameters and serum CRP levels were measured only after two months following SRP. For group A, B1, and B2 (the readings recorded after SRP) the mean gingival index scores were 0.146, 2.437, and 1.052, respectively, while the plaque index was 0.414, 2.499, and 0.954, respectively. Probing pocket depth (PPD) and clinical attachment loss (CAL) showed statistically significant differences between three groups, with higher values in patients with periodontitis before intervention (2.196 ± 0.49; 1.490 ± 0.23), respectively. Healthy controls (Group A) had a C-reactive protein level of 0.04820 mg/dL, while group B1 (test) had 1.678 mg/dL and 0.8892 mg/dL (group B2). C-reactive protein levels were observed to be greater in the test group (groups B1 and B2), and these differences were statistically significant ( < 0.001). Chronic periodontitis enhances blood levels of systemic inflammatory markers like CRP, which has been reduced by periodontal treatment with SRP.
本研究旨在量化牙周健康人群的血清C反应蛋白（CRP）值，探讨血清CRP水平与慢性牙周炎之间的关系，以及龈上洁治和根面平整（SRP）对血清CRP水平的影响。该研究纳入了100名全身健康的成年人（n = 100；50名男性和50名女性），他们被分为两组：A组（对照组）n = 50，为牙周健康受试者；B组（试验组）n = 50，为慢性牙周炎受试者。试验组（B组）进一步随机分为两组：B1组（n = 25）和B2组（n = 25）。A组仅测量一次临床参数和血清CRP水平，B1组受试者在SRP治疗前测量。B2组受试者仅在SRP治疗两个月后测量临床参数和血清CRP水平。对于A组、B1组和B2组（SRP治疗后记录的读数），平均牙龈指数评分分别为0.146、2.437和1.052，而菌斑指数分别为0.414、2.499和0.954。探诊深度（PPD）和临床附着丧失（CAL）在三组之间存在统计学显著差异，干预前牙周炎患者的值更高（分别为2.196±0.49；1.490±0.23）。健康对照组（A组）的C反应蛋白水平为0.04820mg/dL，而B1组（试验组）为1.678mg/dL，B2组为0.8892mg/dL。试验组（B1组和B2组）的C反应蛋白水平更高，且这些差异具有统计学显著性（P < 0.001）。慢性牙周炎会提高全身炎症标志物如CRP的血液水平，而SRP牙周治疗可使其降低。
