Eyal Ophir, Ben-Dov Iddo Z
Department of Nephrology and Hypertension, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Diagnostics (Basel). 2023 Jul 26;13(15):2485. doi: 10.3390/diagnostics13152485.
The blood pressure load (BPL) is commonly defined as the percentage of readings in a 24-h ambulatory blood pressure monitoring (ABPM) study above a certain threshold, usually the upper normal limit. While it has been studied since the 1990s, the benefits of using this index have not been clearly demonstrated in adults. We present the first review on the associations of BPL with target organ damage (TOD) and clinical outcomes in adults, the major determinants for its role and utility in blood pressure measurement. We emphasize studies which evaluated whether BPL has added benefit to the average blood pressure indices on ABPM in predicting adverse outcomes.
PubMed search for all English language papers mentioning ABPM and BPL.
While multiple studies assessed this question, the cumulative sample size is small. Whereas the associations of BPL with various TODs are evident, the available literature fails to demonstrate a clear and consistent added value for the BPL over the average blood pressure indices.
There is a need for prospective studies evaluating the role of BPL in blood pressure measurement. The current literature does not provide sound support for the use of BPL in clinical decisions.
血压负荷（BPL）通常定义为24小时动态血压监测（ABPM）研究中高于特定阈值（通常为正常上限）的读数百分比。自20世纪90年代以来，人们一直在对其进行研究，但在成年人中使用该指标的益处尚未得到明确证实。我们首次综述了成人中BPL与靶器官损害（TOD）及临床结局的关联，这是其在血压测量中作用和效用的主要决定因素。我们重点关注那些评估BPL在预测不良结局方面是否比ABPM上的平均血压指标更具附加益处的研究。
在PubMed上搜索所有提及ABPM和BPL的英文论文。
虽然多项研究评估了这个问题，但累积样本量较小。虽然BPL与各种TOD的关联是明显的，但现有文献未能证明BPL相对于平均血压指标具有明确且一致的附加价值。
需要进行前瞻性研究来评估BPL在血压测量中的作用。目前的文献并未为在临床决策中使用BPL提供有力支持。
