高剂量α-生育酚预防多柔比星引起的脱发
High-dose alpha-tocopherol as a preventive of doxorubicin-induced alopecia.
作者信息
Perez J E, Macchiavelli M, Leone B A, Romero A, Rabinovich M G, Goldar D, Vallejo C
出版信息
Cancer Treat Rep. 1986 Oct;70(10):1213-4.
PMID:3756942
Abstract
The effectiveness of alpha-tocopherol acetate as a preventive of doxorubicin-induced alopecia was evaluated in 20 patients with different types of solid tumors. All received therapy containing doxorubicin in a dose range of 50-60 mg/m2/cycle of treatment. The observed hair loss was severe in 90% and moderate in 10% of the patients. No protective activity of alpha-tocopherol was demonstrated in this trial.
摘要
对20例不同类型实体瘤患者评估了醋酸α-生育酚预防多柔比星诱导脱发的效果。所有患者均接受含多柔比星的治疗，治疗周期剂量范围为50-60mg/m²。观察到90%的患者脱发严重，10%的患者脱发中度。该试验未证明α-生育酚有保护作用。
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