Academic Unit of Gastroenterology, Sheffield Teaching Hospitals, Sheffield S10 2JF, UK.
Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield S10 2TN, UK.
Nutrients. 2023 Aug 4;15(15):3461. doi: 10.3390/nu15153461.
INTRODUCTION: The role of a gluten-free diet (GFD) in Non-Coeliac Gluten/Wheat Sensitivity (NCGWS) is unclear. We present the largest study comparing adherence to a GFD in patients with Coeliac Disease (CD) and NCGWS and assess its impact on quality of life (QoL) and sleep in patients with NCGWS. METHODS: Patients with NCGWS at a tertiary centre completed the Coeliac Disease Adherence Test (CDAT), Coeliac Symptom Index (CSI) and Sleep Condition Indicator (SCI). Higher CDAT scores indicate worse adherence, higher CSI scores indicate poorer QoL, and higher SCI scores indicate better sleep. CDAT scores were correlated with CSI and SCI scores. A second group of patients with CD completed the CDAT questionnaire only. Results were compared with the CDAT responses from the NCGWS group. RESULTS: For the NCGWS cohort ( = 125), the median CDAT score was 17/35, indicating poor adherence. The median CSI score was 44/80, with 40% of scores associated with a poor QoL. The median SCI score was 14/32, and DSM-V criteria for insomnia was met by 42% of patients. There was a positive correlation between CSI and CDAT scores (r = 0.59, < 0.0001) and a negative correlation between SCI and CDAT scores (r = -0.37, = 0.0002). In the CD cohort ( = 170), the median CDAT score was 13/35. Patients with NCGWS had poorer adherence compared to CD (CDAT: 17.0 vs. 13.0, respectively, = 0.0001). CONCLUSION: Patients with NCGWS adhere to a GFD less than those with CD. Poorer adherence to a GFD in patients with NCGWS correlates with a worse QoL and sleep performance.
简介：无麸质饮食（GFD）在非乳糜泻麸质/小麦敏感（NCGWS）中的作用尚不清楚。我们报告了一项比较乳糜泻（CD）和 NCGWS 患者对 GFD 依从性的最大研究，并评估了其对 NCGWS 患者生活质量（QoL）和睡眠的影响。
方法：在一家三级中心，NCGWS 患者完成了乳糜泻依从性测试（CDAT）、乳糜泻症状指数（CSI）和睡眠状况指标（SCI）。更高的 CDAT 分数表示较差的依从性，更高的 CSI 分数表示较差的 QoL，更高的 SCI 分数表示更好的睡眠。CDAT 分数与 CSI 和 SCI 分数相关。第二组 CD 患者仅完成了 CDAT 问卷。结果与 NCGWS 组的 CDAT 反应进行了比较。
结果：对于 NCGWS 队列（= 125），CDAT 评分中位数为 17/35，表明依从性差。CSI 评分中位数为 44/80，其中 40%的评分与较差的 QoL 相关。SCI 评分中位数为 14/32，42%的患者符合 DSM-V 失眠标准。CSI 和 CDAT 评分之间存在正相关（r = 0.59，<0.0001），而 SCI 和 CDAT 评分之间存在负相关（r = -0.37，= 0.0002）。在 CD 队列（= 170）中，CDAT 评分中位数为 13/35。与 CD 相比，NCGWS 患者的依从性较差（CDAT：17.0 与 13.0，分别，= 0.0001）。
结论：NCGWS 患者对 GFD 的依从性低于 CD 患者。NCGWS 患者对 GFD 的依从性较差与 QoL 和睡眠表现较差相关。
Frontline Gastroenterol. 2020-10-27
Aliment Pharmacol Ther. 2016-9
Nutrients. 2025-4-30
Dig Dis Sci. 2023-4
Aliment Pharmacol Ther. 2022-7
Medicina (Kaunas). 2021-5-24
Healthcare (Basel). 2020-10-14
Crit Rev Food Sci Nutr. 2022
BMC Gastroenterol. 2020-8-6
Zotero 插件