ADOLOR Research Group, Department of Medical-Surgical Therapy, Faculty of Medicine and Health Sciences, Extremadura University, 06006 Badajoz, Spain.
Mathematics Department, Faculty of Medicine and Health Sciences, Extremadura University, 06006 Badajoz, Spain.
Nutrients. 2023 Aug 5;15(15):3469. doi: 10.3390/nu15153469.
Fibromyalgia (FM) is characterized by chronic widespread pain, as well as anxiety, sadness, and depression. These symptoms are present in most patients and have a negative impact on their daily, family, and social life. The role of neurotransmitters in the pathophysiology of FM has been extensively discussed. The scientific evidence shows that levels of serotonin are decreased in patients with FM. Numerous studies support the beneficial effects that moderate wine consumption has on the body, with cardiovascular, endocrine, bone, and muscle improvements.
The objective of this pilot study was to assess whether light consumption of red wine improves the main symptoms of FM.
The study consisted of an experimental study with a control group with a total of 60 women diagnosed with FM following the American College of Rheumatology's criteria. The experimental group ingested 15 g of alcohol per day, in the form of red wine, over a period of four weeks. The outcome measures were: the level of pain in tender points, sadness, anxiety, depression, and quality of life. The assessments tools were: tender point graphics, the visual analogue scale (for the assessment of pain and sadness), the Hamilton Anxiety Scale, the Hamilton Depression Rating Scale, and the Fibromyalgia Impact Questionnaire. The measurements were completed before and after the consumption of red wine. In addition, the differences between groups were evaluated in terms of drug consumption in the pre-intervention and follow-up phases.
Statistically significant improvements were obtained in the wine ingestion group for the variables of pain ( = 0.038), tender points ( < 0.001), and anxiety ( = 0.028). An improvement in the mean values was observed in favor of the experimental group for the variables of sadness, depression, and quality of life. The differences observed in the changes seen in the groups that were in favor of the wine ingestion group should not be attributed to the consumption of drugs but to the fact that the experimental group had a light intake of red wine.
The results of this pilot study suggest a potential relationship between alcohol intake through the light consumption of red wine as part of the patients' diet and the improvement of the main symptoms of fibromyalgia. Future studies are necessary to confirm these preliminary data; a bigger sample and a controlled diet should be considered, and the mechanisms through which improvements are achieved should be analyzed.
纤维肌痛症（FM）的特征是慢性广泛性疼痛，以及焦虑、悲伤和抑郁。这些症状在大多数患者中存在，并对他们的日常生活、家庭和社交生活产生负面影响。神经递质在 FM 的病理生理学中的作用已经被广泛讨论。科学证据表明，FM 患者的血清素水平降低。许多研究支持适量饮酒对身体的有益影响，包括心血管、内分泌、骨骼和肌肉的改善。
本初步研究的目的是评估轻度饮用红葡萄酒是否能改善 FM 的主要症状。
该研究包括一个实验组和一个对照组的实验研究，共有 60 名女性被诊断为 FM，符合美国风湿病学院的标准。实验组每天摄入 15 克酒精，以红葡萄酒的形式，持续四周。主要的结局指标是：压痛点的疼痛程度、悲伤、焦虑、抑郁和生活质量。评估工具是：压痛点图、视觉模拟量表（用于评估疼痛和悲伤）、汉密尔顿焦虑量表、汉密尔顿抑郁量表和纤维肌痛影响问卷。在饮用红葡萄酒前后完成了测量。此外，还评估了在干预前和随访阶段药物使用方面的组间差异。
在饮酒组中，疼痛（ = 0.038）、压痛点（ < 0.001）和焦虑（ = 0.028）等变量有显著改善。实验组的悲伤、抑郁和生活质量等变量的平均值有所改善。观察到的组间变化差异不应归因于药物的使用，而应归因于实验组轻度摄入红葡萄酒。
本初步研究的结果表明，通过轻度饮用红葡萄酒作为患者饮食的一部分来摄入酒精，与改善纤维肌痛的主要症状之间可能存在关联。需要进一步的研究来证实这些初步数据；应该考虑更大的样本和对照饮食，并分析改善的机制。
