Chronic Pain and Fatigue Research Center, Department of Anesthesiology, Chronic Pain and Fatigue Research Center.
Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Pain Med. 2018 Dec 1;19(12):2515-2527. doi: 10.1093/pm/pny032.
Moderate alcohol consumption has been associated with improved health outcomes including reduced risk of heart disease; however, less is known regarding alcohol's effects on chronic pain. The aim of this study was to assess associations between pain, fibromyalgia symptoms, and moderate alcohol use in a large chronic pain sample.
A total of 2,583 new chronic pain patients presenting at a university pain clinic reported alcohol use and completed validated measures; 592 (23%) patients reported drinking, with 502 (85%) classified as moderate drinkers (females ≤7 and males ≤14 drinks/wk). General linear models (GLM) assessed the effects of moderate drinking on pain and symptom outcomes. The sample was stratified by gender and fibromyalgia (FM) status in secondary analyses.
Moderate alcohol users reported significantly lower FM symptoms (widespread pain and symptom severity), pain severity, interference, anxiety, depression, and catastrophizing, and they reported higher physical function. Similar findings were observed in gender-stratified analysis, minus associations with FM symptom severity in females and anxiety in males. In patients meeting FM criteria, moderate drinking was associated with lower pain severity, interference, and depression, and higher physical function. Results in non-FM patients were similar to the total sample.
Moderate alcohol consumption in chronic pain patients was associated with decreased pain severity and interference, fewer painful body areas, lower somatic and mood symptoms, and increased physical function. A similar effect was observed in non-FM patients, but to a lesser extent in FM patients, suggesting chronic pain patients with less centralized forms of pain may benefit most from moderate alcohol consumption.
适量饮酒与改善健康结果相关，包括降低心脏病风险；然而，关于酒精对慢性疼痛的影响知之甚少。本研究旨在评估大量慢性疼痛样本中疼痛、纤维肌痛症状与适量饮酒之间的关联。
共有 2583 名新的慢性疼痛患者在一所大学疼痛诊所就诊，报告了饮酒情况并完成了有效的测量；592 名（23%）患者报告饮酒，其中 502 名（85%）被归类为适量饮酒者（女性≤7 次，男性≤14 次/周）。一般线性模型（GLM）评估了适量饮酒对疼痛和症状结果的影响。在二级分析中，按性别和纤维肌痛（FM）状态对样本进行分层。
适量饮酒者报告的 FM 症状（广泛疼痛和症状严重程度）、疼痛严重程度、干扰、焦虑、抑郁和灾难化程度显著较低，且他们报告的身体功能较高。在性别分层分析中观察到类似的发现，除了女性 FM 症状严重程度和男性焦虑与适量饮酒之间的关联外。在符合 FM 标准的患者中，适量饮酒与较低的疼痛严重程度、干扰和抑郁以及较高的身体功能相关。非 FM 患者的结果与总样本相似。
慢性疼痛患者适量饮酒与疼痛严重程度和干扰降低、疼痛部位减少、躯体和情绪症状减轻以及身体功能增加相关。在非 FM 患者中观察到类似的效果，但在 FM 患者中效果较小，这表明疼痛表现为非中枢化形式的慢性疼痛患者可能从适量饮酒中获益最大。
