Lipton A, Morris I D
Cancer Chemother Pharmacol. 1986;18(1):17-20. doi: 10.1007/BF00253056.
Tamoxifen, an oestrogen receptor antagonist and an effective treatment for breast carcinoma, has recently been shown to possess spasmolytic activity in smooth muscle. Tamoxifen in vitro inhibited the contraction of smooth muscle from rat myometrium and aorta produced by exogenous calcium. At the same concentration tamoxifen did not affect the uptake of calcium into the muscle. The importance of calcium in cell proliferation suggests that some of the unexplained antitumor activity of the oestrogen antagonists may be accounted for by intracellular calcium antagonism.
他莫昔芬是一种雌激素受体拮抗剂，也是治疗乳腺癌的有效药物，最近已被证明在平滑肌中具有解痉活性。他莫昔芬在体外可抑制外源性钙引起的大鼠子宫肌层和平滑肌的收缩。在相同浓度下，他莫昔芬不影响肌肉对钙的摄取。钙在细胞增殖中的重要性表明，雌激素拮抗剂一些无法解释的抗肿瘤活性可能是由细胞内钙拮抗作用引起的。
