Burton N K, Barnett M J, Aherne G W, Evans J, Douglas I, Lister T A
Cancer Chemother Pharmacol. 1986;18(1):90-1. doi: 10.1007/BF00253074.
The effect of food on the bioavailability of 6-mercaptopurine (6-MP) has been investigated. Seven patients were studied on two separate occasions. On the first occasion 6-MP was administered p.o. after an overnight fast and on the second, 15 min after a standard breakfast. 6-MP concentrations were determined by high-performance liquid chromatography. Variable plasma drug levels were observed between individual subjects in the fasting state. The peak levels of 6-MP were lower and took longer to be achieved following administration after a standard breakfast than after an overnight fast. In two subjects levels were undetectable (less than 20 ng/ml). In view of these observations it is suggested that 6-MP should be administered before food if maximum blood levels are to be achieved.
已对食物对6-巯基嘌呤（6-MP）生物利用度的影响进行了研究。七名患者在两个不同的时间段接受了研究。第一次，在禁食过夜后口服6-MP；第二次，在标准早餐后15分钟口服。通过高效液相色谱法测定6-MP浓度。在禁食状态下，个体受试者之间观察到血浆药物水平存在差异。与禁食过夜后给药相比，标准早餐后给药后6-MP的峰值水平较低，且达到峰值所需时间更长。在两名受试者中，药物水平检测不到（低于20 ng/ml）。鉴于这些观察结果，建议如果要达到最大血药浓度，6-MP应在进食前给药。
