Toffaletti J, Christenson R H, Mullins S, Harris R E
Clin Chem. 1986 Oct;32(10):1849-53.
We studied 16 patients undergoing open-heart surgery and heart-lung bypass, to examine the relationship between ionized calcium and lactate. Blood was sampled at successive stages of the operation for measurement of ionized and total calcium, lactate, blood gases, pH, hematocrit, and other constituents. We found that correlations between ionized calcium and lactate were positive and statistically significant (p less than 0.05), both among and within patients. The linear regression of ionized calcium on lactate remained highly significant (p less than 0.0001) after adjustment for variability among patients and across operative stages as well as after correction for pH and hemodilution. The significant regressions between calcium and lactate, both before and after administration of calcium, indicate a relationship for calcium and lactate in patients undergoing open-heart surgery.
我们研究了16例接受心脏直视手术和心肺转流术的患者，以检查离子钙与乳酸之间的关系。在手术的连续阶段采集血液，用于测量离子钙和总钙、乳酸、血气、pH值、血细胞比容及其他成分。我们发现，无论是在患者之间还是患者自身，离子钙与乳酸之间的相关性均为正且具有统计学意义（p<0.05）。在对患者之间及不同手术阶段的变异性进行校正后，以及在对pH值和血液稀释进行校正后，离子钙对乳酸的线性回归仍具有高度显著性（p<0.0001）。补钙前后钙与乳酸之间的显著回归表明，在接受心脏直视手术的患者中，钙与乳酸之间存在一种关系。
