tau蛋白、ADNP蛋白与性别

Tau, ADNP, and sex.

作者信息

Gozes Illana

机构信息

Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

出版信息

Cytoskeleton (Hoboken). 2024 Jan;81(1):16-23. doi: 10.1002/cm.21776. Epub 2023 Aug 12.

DOI:10.1002/cm.21776

PMID:37572043

Abstract

With 50 years to the original discovery of Tau, I gave here my perspective, looking through the prism of activity-dependent neuroprotective protein (ADNP), and the influence of sex. My starting point was vasoactive intestinal peptide (VIP), a regulator of ADNP. I then moved to the original discovery of ADNP and its active neuroprotective site, NAP, drug candidate, davunetide. Tau-ADNP-NAP interactions were then explained with emphasis on sex and future translational medicine.

摘要

自最初发现Tau蛋白至今已有50年，在此我阐述一下自己的观点，透过活性依赖神经保护蛋白（ADNP）及性别的影响这一视角来看。我的出发点是血管活性肠肽（VIP），它是ADNP的一种调节剂。接着我谈到了ADNP及其活性神经保护位点NAP（药物候选物达武奈肽）的最初发现。随后解释了Tau-ADNP-NAP之间的相互作用，并重点讨论了性别因素及未来的转化医学。