The nature of gastric secretions in a patient with Zollinger-Ellison syndrome without peptic ulceration.

A study has been made of the gastric secretions from a patient with Zollinger-Ellison syndrome without peptic ulceration, before and after treatment with cimetidine. The amount of non-diffusable glycoconjugates was measured as an index of mucin output, and found to be within normal limits. Cimetidine, which greatly reduced the volume of secretions, had no effect on the non-diffusable glycoconjugates. These results may explain the absence of peptic ulceration in certain patients with this syndrome.