Department of Structural and Functional Biology, Institute of Bioscience of Botucatu, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Department of Histology, Embryology and Cell Biology, Institute of Biological Sciences, Federal University of Goiás (UFG), Goiânia, Goiás, Brazil.
Comp Biochem Physiol A Mol Integr Physiol. 2023 Nov;285:111502. doi: 10.1016/j.cbpa.2023.111502. Epub 2023 Aug 10.
The muscle phenotype of fish is regulated by numerous factors that, although widely explored, still need to be fully understood. In this context, several studies aimed to unravel how internal and external stimuli affect the muscle growth of these vertebrates. The pacu (Piaractus mesopotamicus) is a species of indeterminate muscular growth that quickly reaches high body weight. For this reason, it adds great importance to the productive sector, along with other round fish. In this context, we aimed to compile studies on fish biology and skeletal muscle growth, focusing on studies by our research group that used pacu as an experimental model along with other species. Based on these studies, new muscle phenotype regulators were identified and explored in vivo, in vitro, and in silico studies, which strongly contribute to advances in understanding muscle growth mechanisms with future applications in the productive sector.
鱼类的肌肉表型受许多因素的调节，尽管这些因素已经得到了广泛的研究，但仍需要进一步深入了解。在这方面，有几项研究旨在揭示内部和外部刺激如何影响这些脊椎动物的肌肉生长。巨臀脂鲤（Piaractus mesopotamicus）是一种肌肉生长不定型的鱼类，它能迅速达到很高的体重。因此，它与其他圆口鱼类一起，对生产部门具有重要意义。在这方面，我们旨在收集有关鱼类生物学和骨骼肌肉生长的研究，重点是我们研究小组的研究，该研究使用巨臀脂鲤作为实验模型，同时还使用了其他物种。基于这些研究，我们在体内、体外和计算机模拟研究中鉴定和探索了新的肌肉表型调节因子，这为理解肌肉生长机制的进展做出了重要贡献，并为生产部门的未来应用提供了可能。
