三种不同判别分析方法检测苯丙酮尿症基因携带者的相对可靠性。

Relative reliability of three different discriminant analysis methods for detecting PKU gene carriers.

作者信息

Wenger S L, Vieira P W, Breck J M, Steele M W

出版信息

Clin Genet. 1986 Jul;30(1):38-40. doi: 10.1111/j.1399-0004.1986.tb00566.x.

DOI:10.1111/j.1399-0004.1986.tb00566.x

Abstract

A previously derived discriminant function for detecting classical PKU gene carriers without a priori pedigree probability was reevaluated using a large sample size. The test involves fluorometric measurement of fasting phenylalanine and tyrosine plasma levels. Among 75 controls and 45 known carriers, 95% could be classified as to their carrier status with greater than 98% accuracy. The accuracy of our method in classifying our population compared favorably to that of two other discriminant analysis methods requiring a priori probability.

摘要

利用大样本重新评估了先前推导的用于检测无先证者系谱概率的经典苯丙酮尿症基因携带者的判别函数。该检测涉及荧光法测量空腹血浆苯丙氨酸和酪氨酸水平。在75名对照者和45名已知携带者中，95%的人能够以大于98%的准确率被分类为携带者状态。与另外两种需要先验概率的判别分析方法相比，我们的方法在对我们的人群进行分类时的准确性更具优势。