The vascular system in bone. Its importance and relevance to clinical practice.

Experimentally proven principles on the effect of changes in bone blood flow on molecular transport in bone and on the factors that affect these changes in both flow under physiologic and pharmacologic conditions clarify the changes that occur in bone in response to certain clinical problems, such as the effect of blood flow in fracture healing. The results of using these principles in establishing a method of quantitative bone scanning are presented.