Mackman G, Brightbill F S, Optiz J M
Am J Ophthalmol. 1979 Apr;87(4):497-502. doi: 10.1016/0002-9394(79)90238-1.
Nineteen patients with aniridia and one patient with bilateral iris colobomata from eight families were examined for corneal abnormalities. Thirty-six eyes revealed changes that are consistent with a progressive corneal dystrophy. These changes begin in the corneal periphery in the early years of life and progress to the corneal center with increasing age. This dystrophy has been staged into four typical clinical patterns. Central corneal scarring, and in some cases, ulceration may occur, which may be a significant threat to vision.
对来自8个家庭的19例无虹膜患者和1例双侧虹膜缺损患者进行了角膜异常检查。36只眼睛出现了与进行性角膜营养不良相符的变化。这些变化在生命早期始于角膜周边，随着年龄增长向角膜中心发展。这种营养不良已被分为四种典型的临床模式。可能会出现中央角膜瘢痕，在某些情况下还会出现溃疡，这可能对视力构成重大威胁。
