Gaston Symielle A, Alhasan Dana M, Jones Rodney D, Braxton Jackson W, Kesner Andrew J, Buxton Orfeu M, Jackson Chandra L
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
Department of Biobehavioral Health, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania, USA.
Sleep Health. 2023 Oct;9(5):587-595. doi: 10.1016/j.sleh.2023.06.003. Epub 2023 Aug 11.
Research investigating cannabis use and sleep health is limited, and results are mixed. Few studies were nationally representative with racially-ethnically diverse samples or assessed potential modifiers. Our objective was to investigate cross-sectional associations between reported cannabis use and sleep disturbances by potential modifiers among non-Hispanic White, non-Hispanic Black, and Hispanic/Latino men and women in the United States.
We used nationally representative National Comorbidity Survey-Replication data collected from 2001 to 2003 among 3929 adults. Poisson regression with robust variance estimated prevalence ratios (PR) and 95% confidence intervals of patterns of sleep disturbances identified through latent class analysis. Models adjusted for sociodemographic, health behavior, and clinical characteristics were stratified by race-ethnicity and by race-ethnicity along with sex/gender, and age, separately.
Over half of adults reported cannabis use (52%-ever/lifetime vs 48%-never). We identified two latent classes: multiple sleep disturbances with daytime sleepiness and no sleep disturbances with some daytime sleepiness. Prevalence of multiple sleep disturbances with daytime sleepiness was higher among participants reporting lifetime cannabis use (23% vs 20%). Associations did not vary by race-ethnicity or sex/gender. Lifetime vs never cannabis use was marginally associated with a higher prevalence of multiple sleep disturbances with daytime sleepiness only among adults aged 25-29years (PR=1.09 [95% confidence interval: 1.00-1.18]; eg, PR=1.00 [0.97-1.03], p=0.03).
Associations between cannabis use and sleep may vary by age. Replication with more recent data and prospective studies that investigate intersectional identities among diverse populations with objective assessments are warranted.
关于大麻使用与睡眠健康的研究有限,结果也不一致。很少有研究具有全国代表性,样本包含不同种族和族裔,或评估了潜在的调节因素。我们的目的是调查美国非西班牙裔白人、非西班牙裔黑人以及西班牙裔/拉丁裔男性和女性中,报告的大麻使用与睡眠障碍之间按潜在调节因素划分的横断面关联。
我们使用了2001年至2003年从3929名成年人中收集的具有全国代表性的国家共病调查复制数据。通过潜在类别分析确定睡眠障碍模式的泊松回归,估计患病率比(PR)和95%置信区间。针对社会人口统计学、健康行为和临床特征进行调整的模型,分别按种族和族裔以及按种族和族裔与性别和年龄进行分层。
超过一半的成年人报告使用过大麻(52%——曾经/一生使用过,48%——从未使用过)。我们确定了两个潜在类别:伴有日间嗜睡的多种睡眠障碍和伴有一些日间嗜睡的无睡眠障碍。报告一生使用过大麻的参与者中,伴有日间嗜睡的多种睡眠障碍患病率更高(23%对20%)。关联在种族和族裔或性别方面没有差异。仅在25至29岁的成年人中,一生使用大麻与从不使用大麻相比,伴有日间嗜睡的多种睡眠障碍患病率略高(PR = 1.09 [95%置信区间:1.00 - 1.18];例如,PR = 1.00 [0.97 - 1.03],p = 0.03)。
大麻使用与睡眠之间的关联可能因年龄而异。有必要用更新的数据进行重复研究,并开展前瞻性研究,通过客观评估调查不同人群中的交叉身份。