Douradinha Bruno
Nykode Therapeutics ASA, Oslo Science Park, Gaustadalléen 21, 0349 Oslo, Norway.
Trends Parasitol. 2023 Oct;39(10):808-811. doi: 10.1016/j.pt.2023.07.008. Epub 2023 Aug 12.
Attenuated plasmodial sporozoite-induced immune response includes intrahepatic nitric oxide (NO) production, which promotes apoptosis of infected hepatocytes and consequent parasite clearance. NO in excess reacts with superoxide, forming peroxynitrite, a powerful cytotoxic agent. Here, I suggest that peroxynitrite proapoptotic action may contribute to the attenuated malarial sporozoite-mediated protection.
减毒疟原虫子孢子诱导的免疫反应包括肝内一氧化氮（NO）的产生，这促进了被感染肝细胞的凋亡以及随后的寄生虫清除。过量的NO与超氧化物反应，形成过氧亚硝酸盐，一种强大的细胞毒剂。在此，我认为过氧亚硝酸盐的促凋亡作用可能有助于减毒疟原虫子孢子介导的保护作用。
