Sehrawat Nirmala, Yadav Mukesh, Kumar Sunil, Devi Ashwanti, Singh Rajbir, Sharma Varruchi, Dhama Kuldeep, Lorenzo Jose M, Sharma Anil Kumar
Department of Bio-Sciences and Technology, M.M.E.C., Maharishi Markandeshwar (deemed to be University), Mullana, Ambala, Haryana, India.
Department of Microbiology, Faculty of Bio-medical Sciences, Kampala International University, Kampala, Uganda.
Biotechnol Appl Biochem. 2023 Dec;70(6):2002-2016. doi: 10.1002/bab.2505. Epub 2023 Aug 13.
Cancer is still a major challenge for humans. In recent years, researchers have focused on plant-based metabolites as a safe, efficient, alternative or combinatorial, as well as cost-effective preventive strategy against carcinogenesis. Mung bean is an important nutritious legume, and known for providing various health benefits due to various bioactive phytochemicals and easily digestible proteins. Regular intake of mung bean helps to regulate metabolism by affecting the growth and survival of good microbes in the host gut. Mung bean has also been reported to have anti-inflammatory, antioxidant, antiproliferative, and immunomodulatory properties. These properties may possess the preventive potential of mung bean against carcinogenesis. Bibliographic databases for peer-reviewed research literature were searched through a structured conceptual approach using focused review questions on mung beans, anticancer, therapeutics, and functional foods along with inclusion/exclusion criteria. For the appraisal of the quality of retrieved articles, standard tools were employed. A deductive qualitative content analysis methodology further led us to analyze outcomes of the research and review articles. The present review provides recent updates on the anticancer potential of mung bean and the possible mechanism of action thereof to prevent carcinogenesis and metastasis. Extensive research on the active metabolites and mechanisms of action is required to establish the anticancer potential of mung bean. Keeping the above facts in view, mung bean should be investigated for its bioactive compounds, to be considered as functional food of the future.
癌症仍然是人类面临的重大挑战。近年来，研究人员将重点放在了基于植物的代谢物上，将其作为一种安全、高效、可替代或联合使用的、且具有成本效益的抗癌预防策略。绿豆是一种重要的营养豆类，因其含有多种生物活性植物化学物质和易于消化的蛋白质而具有多种健康益处。经常食用绿豆有助于通过影响宿主肠道中有益微生物的生长和存活来调节新陈代谢。据报道，绿豆还具有抗炎、抗氧化、抗增殖和免疫调节特性。这些特性可能使绿豆具有抗癌潜力。通过结构化概念方法，使用关于绿豆、抗癌、治疗学和功能性食品的重点综述问题以及纳入/排除标准，检索了同行评审研究文献的书目数据库。为了评估检索到的文章的质量，采用了标准工具。演绎性定性内容分析方法进一步引导我们分析研究和综述文章的结果。本综述提供了绿豆抗癌潜力及其预防癌变和转移的可能作用机制的最新进展。需要对活性代谢物及其作用机制进行广泛研究，以确定绿豆的抗癌潜力。鉴于上述事实，应研究绿豆的生物活性化合物，以便将其视为未来的功能性食品。
