Copenhagen Research Center for Mental Health-CORE, Mental Health Center Copenhagen, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Danish Research Institute of Suicide Prevention, Mental Health Center Copenhagen, Copenhagen, Denmark.
Addiction. 2023 Dec;118(12):2440-2448. doi: 10.1111/add.16311. Epub 2023 Aug 13.
Substance-induced psychosis has previously been linked to an excess risk of suicide; however, the association between substance-induced psychosis and suicide attempt has hitherto not been investigated. We investigated whether substance-induced psychosis was associated with a higher risk of subsequent suicide attempt.
Nation-wide prospective register-based cohort study.
Denmark.
All people living in Denmark aged 13 years or more during 1995 to 2017.
Substance-induced psychosis and suicide attempts were identified through hospital records as ICD-10 codes.
A total of 8900 (78.8% males) individuals were diagnosed with a substance-induced psychosis, and 740 of these had a suicide attempt during follow-up. People with a substance-induced psychosis had a higher risk of a subsequent suicide attempt [hazard ratio (HR) = 13.4, 95% confidence interval (CI) = 12.4-14.4] when compared with the general population. The highest hazard ratios were found for psychosis induced by opioids (HR = 26.4, 95% CI = 18.2-38.2); alcohol (HR = 17.7, 95% CI = 15.2-20.6); sedatives (HR = 17.2, 95% CI = 8.9-33.0); and cocaine (HR = 15.6, 95% CI = 10.7-22.8), while cannabis-induced psychosis was linked to an HR of 8.9 (95% CI = 7.7-10.3). Approximately 15% of patients with substance-induced psychosis had had a suicide attempt within 20 years of their substance-induced psychosis diagnosis.
In Denmark, substance-induced psychosis appears to be strongly associated with subsequent suicide attempt, underscoring the importance of attention and better follow-up for this patient group.
物质所致精神障碍先前与自杀风险增加有关；然而，物质所致精神障碍与自杀未遂之间的关联尚未得到研究。我们调查了物质所致精神障碍是否与随后自杀未遂的风险增加有关。
全国范围内的前瞻性基于登记的队列研究。
丹麦。
1995 年至 2017 年期间，丹麦所有年龄在 13 岁及以上的居民。
物质所致精神障碍和自杀未遂通过医院记录以 ICD-10 编码确定。
共有 8900 人（78.8%为男性）被诊断为物质所致精神障碍，其中 740 人在随访期间有自杀未遂。与一般人群相比，患有物质所致精神障碍的人随后自杀未遂的风险更高[风险比（HR）=13.4，95%置信区间（CI）=12.4-14.4]。风险最高的是阿片类物质引起的精神障碍（HR=26.4，95%CI=18.2-38.2）；酒精（HR=17.7，95%CI=15.2-20.6）；镇静剂（HR=17.2，95%CI=8.9-33.0）；可卡因（HR=15.6，95%CI=10.7-22.8），而大麻引起的精神障碍与 HR 为 8.9（95%CI=7.7-10.3）相关。大约 15%的物质所致精神障碍患者在物质所致精神障碍诊断后的 20 年内有过自杀未遂。
在丹麦，物质所致精神障碍似乎与随后的自杀未遂有很强的关联，这突显了关注和更好地随访这一患者群体的重要性。
