The First-Affiliated Hospital of Hunan Normal University, Hunan Provincial People's Hospital, Changsha, Hunan, China.
Hunan Provincial Center for Disease Control and Prevention, Changsha, China.
Front Public Health. 2023 Jul 28;11:1174536. doi: 10.3389/fpubh.2023.1174536. eCollection 2023.
Neonatal meningitis is rare but devastating disease. Multidrug-resistant (MDR, multi-drug resistant) bacteria are a major global health risk. We report an meningitis isolate with multiple resistance patterns and unusual serotype (O75) that caused sudden neonatal death. The isolate was resistant to antibiotics other than cefoperazone/sulbactam and imipenem, challenging the combination of antibiotics commonly used in the empirical treatment of neonatal sepsis. Despite aggressive symptomatic and supportive treatment of the infant based on laboratory tests and clinical practice, the infant eventually died. This is the first case of meningoencephalitis due to serotype O75 reported in China. The presence of highly pathogenic multidrug-resistant microorganisms isolated in neonates underscores the need to implement rapid resistance diagnostic methods and should prompt consideration of alternatives to empiric treatment of neonatal bacterial meningitis.
新生儿脑膜炎罕见但后果严重。耐多药（MDR，多药耐药）细菌是一个主要的全球健康风险。我们报告了一例具有多种耐药模式和不常见血清型（O75）的脑膜炎分离株，该分离株导致新生儿突然死亡。该分离株除头孢哌酮/舒巴坦和亚胺培南外，对其他抗生素均有耐药性，这对新生儿败血症经验性治疗中常用的抗生素组合构成了挑战。尽管根据实验室检测和临床实践，对婴儿进行了积极的对症和支持治疗，但婴儿最终还是死亡了。这是中国首例报告的由血清型 O75 引起的脑膜炎病例。在新生儿中分离出高致病性耐多药微生物，这凸显了需要实施快速耐药诊断方法的必要性，并应促使人们考虑替代经验性治疗新生儿细菌性脑膜炎的方法。
