Khosla Sundeep
Kogod Center on Aging and Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota.
Curr Opin Endocr Metab Res. 2023 Aug;31. doi: 10.1016/j.coemr.2023.100471. Epub 2023 Jun 29.
There is increasing evidence from animal models that bone, in addition to its traditional function of providing structural support for the organism, has a rich network of interactions with multiple other tissues. This perspective focuses on evidence from human studies demonstrating that bone is an endocrine organ regulating energy metabolism, with the specific examples being osteocalcin, lipocalin 2, RANKL, and sclerostin. Conversely, animal studies have also demonstrated that a key hormone regulating energy metabolism, leptin, regulates bone metabolism via the sympathetic nervous system. Studies in humans have established a role for the sympathetic nervous system in regulating bone turnover; indeed, the potential therapeutic benefit of targeting this pathway in humans to prevent postmenopausal bone loss is currently being evaluated.
越来越多来自动物模型的证据表明，骨骼除了具有为机体提供结构支撑的传统功能外，还与多种其他组织有着丰富的相互作用网络。本文观点聚焦于来自人体研究的证据，这些证据表明骨骼是调节能量代谢的内分泌器官，具体例子有骨钙素、lipocalin 2、RANKL和硬化蛋白。相反，动物研究也表明，一种调节能量代谢的关键激素——瘦素，通过交感神经系统调节骨代谢。人体研究已证实交感神经系统在调节骨转换中发挥作用；事实上，目前正在评估针对该途径预防绝经后骨质流失在人体中的潜在治疗益处。
