Gao Qian, Feng Lei, Zhou Weiling, Li Xiaoli, Yin Lanzi, Wang Yuan
Department of Endocrine and Metabolic Diseases, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Aug 7;16:2345-2354. doi: 10.2147/DMSO.S418020. eCollection 2023.
This study aims to investigate the predictive value of non-traditional blood lipid indices for metabolism dysfunction-associated fatty liver disease (MAFLD) in non-overweight/obese patients with type 2 diabetes mellitus (T2DM).
A retrospective observational study was conducted, including non-overweight/obese patients with T2DM who visited the Fourth Hospital of Hebei Medical University between August 2018 and August 2022. The low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio, the triacylglycerol-glucose index (TyG) multiplied by body mass index (BMI), and TyG/HDL-C ratio were calculated.
The study involved 190 participants, of whom 34 were diagnosed with MAFLD (24 males and 10 females), while 156 did not have MAFLD (64 males and 92 females). Multivariable analysis revealed that aspartate transaminase (AST) (OR=1.216, 95% CI: 1.059-1.374, P=0.006), blood uric acid (BUA) (OR=1.017, 95% CI: 1.002-1.032, P=0.022), TyGBMI (OR=1.231, 95% CI: 1.051-1.442, P=0.010), and TyG/HDL-C (OR=3.162, 95% CI: 1.228-8.141, P=0.017) were independently associated with MAFLD. The TyGBMI index exhibited an area under the ROC curve (AUC) of 0.812, with 91.2% sensitivity and 69.2% specificity for MAFLD. The TyG/HDL-C index had an AUC of 0.929, with 85.3% sensitivity and 88.5% specificity for MAFLD.
The results indicate that TyG*BMI and TyG/HDL-C are independently associated with MAFLD in non-overweight/obese patients with T2DM.
本研究旨在探讨非传统血脂指标对非超重/肥胖2型糖尿病（T2DM）患者代谢功能障碍相关脂肪性肝病（MAFLD）的预测价值。
进行一项回顾性观察研究，纳入2018年8月至2022年8月期间就诊于河北医科大学第四医院的非超重/肥胖T2DM患者。计算低密度脂蛋白胆固醇（LDL-C）/高密度脂蛋白胆固醇（HDL-C）比值、甘油三酯-葡萄糖指数（TyG）乘以体重指数（BMI）以及TyG/HDL-C比值。
该研究纳入190名参与者，其中34例被诊断为MAFLD（男性24例，女性10例），156例未患MAFLD（男性64例，女性92例）。多变量分析显示，天冬氨酸转氨酶（AST）（OR=1.216，95%CI：1.059-1.374，P=0.006）、血尿酸（BUA）（OR=1.017，95%CI：1.002-1.032，P=0.022）、TyGBMI（OR=1.231，95%CI：1.051-1.442，P=0.010）以及TyG/HDL-C（OR=3.162，95%CI：1.228-8.141，P=0.017）与MAFLD独立相关。TyGBMI指数的ROC曲线下面积（AUC）为0.812，对MAFLD的敏感度为91.2%，特异度为69.2%。TyG/HDL-C指数的AUC为0.929，对MAFLD的敏感度为85.3%，特异度为88.5%。
结果表明，TyG*BMI和TyG/HDL-C与非超重/肥胖T2DM患者的MAFLD独立相关。
