Varma Anika, Weinstein Jennifer, Seabury Jamison, Rosero Spencer, Zizzi Christine, Dilek Nuran, Heatwole John, Baumgart Megan, Mulford Deborah, Maggiore Ronald, Conrow Lainie, King Jennifer C, Wiens Jacinta, Heatwole Chad
Center for Health + Technology, University of Rochester, CU, Rochester, NY, USA.
Department of Neurology, University of Rochester, Rochester, NY, USA.
Transl Lung Cancer Res. 2023 Jul 31;12(7):1391-1413. doi: 10.21037/tlcr-22-831. Epub 2023 Jul 11.
Individuals with lung cancer (LC) face a variety of symptoms that significantly impact their lives. We use extensive patient input to determine the relative importance and prevalence of these symptoms and identify which demographic features are associated with a higher level of disease burden.
We performed semi-structured qualitative interviews with participants with LC to identify potentially important symptoms. We then conducted a cross-sectional study, in which participants rated the relative importance of 162 individual symptoms covering 14 symptomatic themes. Participant responses were analyzed by age, sex, disability status, disease duration, LC stage, type of treatment received, and smoking history, among other categories.
Our cross-sectional study had 139 participants with LC. The most prevalent symptomatic themes reported by this population were fatigue (85.5%), impaired sleep and daytime sleepiness (73.5%), and emotional issues (73.0%). The symptomatic themes that had the greatest average impact (on a scale of 0 to 4, with 4 being the most impactful) were social role dissatisfaction (1.67), inability to do activities (1.64), and fatigue (1.60). Disability status had the strongest association with symptomatic theme prevalence. LC stage (stage IV), receipt of therapy, and smoking experience were also associated with higher frequency of symptomatic themes.
Individuals with LC face diverse and disease-specific symptoms that affect their daily lives. Patient insight on the prevalence and relative importance of these symptoms is invaluable to advance meaningful therapeutic interventions.
肺癌患者面临多种严重影响其生活的症状。我们通过广泛收集患者意见来确定这些症状的相对重要性和普遍性，并确定哪些人口统计学特征与更高水平的疾病负担相关。
我们对肺癌患者进行了半结构化定性访谈，以确定潜在的重要症状。然后我们开展了一项横断面研究，让参与者对涵盖14个症状主题的162种个体症状的相对重要性进行评分。参与者的回答按年龄、性别、残疾状况、疾病持续时间、肺癌分期、接受的治疗类型和吸烟史等类别进行分析。
我们的横断面研究有139名肺癌患者。该人群报告的最普遍的症状主题是疲劳（85.5%）、睡眠障碍和日间嗜睡（73.5%）以及情绪问题（73.0%）。平均影响最大的症状主题（评分范围为0至4，4表示影响最大）是社会角色不满（1.67）、无法进行活动（1.64）和疲劳（1.60）。残疾状况与症状主题的普遍性关联最强。肺癌分期（IV期）、接受治疗和吸烟经历也与症状主题的较高发生率相关。
肺癌患者面临多种特定于疾病的症状，这些症状会影响他们的日常生活。患者对这些症状的普遍性和相对重要性的见解对于推进有意义的治疗干预非常宝贵。
