Kovács G L, Sarnyai Z, Szabó G, Telegdy G
Drug Alcohol Depend. 1986 Jul;17(4):369-75. doi: 10.1016/0376-8716(86)90087-6.
Acute morphine tolerance was induced in mice by subcutaneous (s.c.) injection of a high dose (30 or 100 mg/kg) of morphine. The degree of tolerance was estimated 5 h later. Intracerebroventricular (i.c.v.) injection of graded doses of oxytocin (OXT) dose-dependently attenuated the development of tolerance. i.c.v. injection of a specific anti-OXT serum, on the other hand, facilitated the development of tolerance. Neither OXT nor anti-OXT serum had any effect on the pain sensitivity in morphine-naive mice; nor did these treatments modify the antinociceptive action of a single morphine treatment. It is concluded that the endogenous OXT of the mouse brain is normally involved in the adaptive response of the organism, leading to the development of morphine tolerance.
通过皮下注射高剂量（30或100毫克/千克）吗啡诱导小鼠产生急性吗啡耐受性。5小时后评估耐受性程度。脑室内注射不同剂量的催产素（OXT）剂量依赖性地减弱了耐受性的发展。另一方面，脑室内注射特异性抗OXT血清则促进了耐受性的发展。OXT和抗OXT血清对未用过吗啡的小鼠的疼痛敏感性均无任何影响；这些处理也未改变单次吗啡处理的镇痛作用。得出的结论是，小鼠脑内的内源性OXT通常参与机体的适应性反应，导致吗啡耐受性的产生。
