Korosteleva T A, Movsesian K S, Nesterova V I, Saprin A N, Meĭia N V
Eksp Onkol. 1986;8(4):59-61.
The paper deals with the carcinostatic and immunomodifying action of synthetic polyelectrolytes containing acid and basic groups as well as of polyampholytes and nonionogenic polymers. Polyacrylic acid was found to possess the highest antitumour and adjuvant activity. The antitumour effect of polyacrylic acid increases with its molecular mass. Introduction of other polymers into a polymer chain of acrylic acid results in a decrease in its antitumour and immunoadjuvant action.
本文论述了含有酸性和碱性基团的合成聚电解质以及聚两性电解质和非离子型聚合物的抗癌和免疫调节作用。发现聚丙烯酸具有最高的抗肿瘤和佐剂活性。聚丙烯酸的抗肿瘤作用随其分子量增加而增强。在丙烯酸聚合物链中引入其他聚合物会导致其抗肿瘤和免疫佐剂作用降低。