Department of Pharmacology, College of Pharmacy, Naval Medical University/Second Military Medical University, Shanghai 200433, China.
National Experimental Teaching Demonstration Center of Pharmacy, Naval Medical University/Second Military Medical University, Shanghai 200433, China.
ACS Chem Neurosci. 2023 Sep 6;14(17):2995-3012. doi: 10.1021/acschemneuro.3c00406. Epub 2023 Aug 14.
Ferroptosis is increasingly being recognized as a key element in the pathogenesis of diverse diseases. Recent studies have highlighted the intricate links between iron metabolism and neurodegenerative disorders. Emerging evidence suggests that iron homeostasis, oxidative stress, and neuroinflammation all contribute to the regulation of both ferroptosis and neuronal health. However, the precise molecular mechanisms underlying the involvement of ferroptosis in the pathological processes of neurodegeneration and its impact on neuronal dysfunction remain incompletely understood. In our Review, we provide a comprehensive analysis and summary of the potential molecular mechanisms underlying ferroptosis in neurodegenerative diseases, aiming to elucidate the disease progression of neurodegeneration. Additionally, we discuss potential therapeutic agents that modulate ferroptosis with the goal of identifying novel drug molecules for the treatment of neurodegenerative disorders.
铁死亡作为多种疾病发病机制的关键因素，正日益受到关注。最近的研究强调了铁代谢与神经退行性疾病之间的复杂联系。新出现的证据表明，铁稳态、氧化应激和神经炎症都有助于调节铁死亡和神经元健康。然而，铁死亡参与神经退行性病变病理过程的精确分子机制及其对神经元功能障碍的影响仍不完全清楚。在本综述中，我们对神经退行性疾病中铁死亡的潜在分子机制进行了全面分析和总结，旨在阐明神经退行性病变的疾病进展。此外，我们还讨论了潜在的调节铁死亡的治疗药物，以期确定治疗神经退行性疾病的新型药物分子。
