肱骨外上髁炎危险因素的荟萃分析。
A meta-analysis of the risk factors for lateral epicondylitis.
作者信息
Chen Qiaojie, Shen Pingping, Zhang Bo, Chen Yang, Zheng Chunli
机构信息
Department of Orthopedics, Ningbo No. 2 Hospital, Ningbo, China.
Department of Gastroenterology, Ningbo Yinzhou No.2 Hospital, Ningbo, China.
出版信息
J Hand Ther. 2024 Jan-Mar;37(1):44-52. doi: 10.1016/j.jht.2023.05.013. Epub 2023 Aug 12.
BACKGROUND
Very few meta-analyses discussed risk factors for lateral epicondylitis (LE), and previous meta-analyses reached conflicting conclusions with each other on some specific risk factors.
PURPOSE
To investigate the risk factors for LE through meta-analysis.
STUDY DESIGN
Meta-analysis.
METHODS
PubMed, Embase, and Web of Science databases were searched for relevant studies in January 2022. Raw data were extracted into a predefined worksheet, and quality analysis was conducted by the Quality in Prognosis Studies (QUIPS) tool. Pooled effect sizes and 95% confidence intervals were calculated. R package "meta" was used for statistical analysis.
RESULTS
22 studies were included in the meta-analysis. Female sex (odds ratio [OR]=1.33 and p-value<0.05), smoking history (OR=1.46 and p-value<0.001), manual labor (OR=2.39 and p-value<0.001), and hypercholesterolemia (OR=1.67 and p-value<0.05) were significant risk factors for LE.
CONCLUSIONS
Female gender, smoking history, manual labor, and hypercholesterolemia could increase the risk of LE. According to an additional literature review, statin treatment for hypercholesterolemia is described as potentially related to the development of LE.
背景
很少有荟萃分析探讨外侧上髁炎（LE）的危险因素，且之前的荟萃分析在一些特定危险因素上得出了相互矛盾的结论。
目的
通过荟萃分析研究LE的危险因素。
研究设计
荟萃分析。
方法
于2022年1月在PubMed、Embase和科学网数据库中检索相关研究。将原始数据提取到预定义的工作表中，并通过预后研究质量（QUIPS）工具进行质量分析。计算合并效应量和95%置信区间。使用R包“meta”进行统计分析。
结果
22项研究纳入荟萃分析。女性（优势比[OR]=1.33，p值<0.05）、吸烟史（OR=1.46，p值<0.001）、体力劳动（OR=2.39，p值<0.001）和高胆固醇血症（OR=1.67，p值<0.05）是LE的显著危险因素。
结论
女性、吸烟史、体力劳动和高胆固醇血症会增加LE的风险。根据一项额外的文献综述，用他汀类药物治疗高胆固醇血症可能与LE的发生有关。
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