从真菌 Penicillium herquei YNJ-35 中分离得到的 ent-Herqueidiketal 和 epi-Peniciherqueinone。
ent-Herqueidiketal and epi-Peniciherqueinone Isolated from a Mushroom Derived Fungus Penicillium herquei YNJ-35.
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 110016, Shenyang, China.
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850, Beijing, China.
出版信息
Chem Biodivers. 2023 Sep;20(9):e202300991. doi: 10.1002/cbdv.202300991. Epub 2023 Sep 4.
A new polyaromatic metabolite, ent-herqueidiketal (1), and a new phenalenone derivative, epi-peniciherqueinone (2), along with twelve known compounds 3-14, were isolated from the fungus Penicillium herquei YNJ-35, a symbiotic fungus of Pulveroboletus brunneopunctatus collected from Nangunhe Nature Reserve, Yunnan Province, China. The structures of 1-14 and the absolute configurations of 1 and 2 were determined by their spectroscopic data or by their single-crystal X-ray diffraction analysis or optical rotation values. Compound 1 showed strong antibacterial activity against Staphylococcus aureus (ATCC 29213) with minimum inhibitory concentration (MIC) of 8 μg/mL. In the cytotoxicity assays, compound 1 showed weak inhibitory activity against breast cancer MCF-7 and mice microglial BV2 cells with half maximal inhibitory concentration (IC ) of 17.58 and 29.56 μM; compound 14 showed stronger cytotoxicity against BV2 and MCF-7 cells with IC values of 6.57 and 10.26 μM.
从采自中国云南省那弄河自然保护区的共生真菌离褶伞属Pulveroboletus 与青霉属Penicillium 的共生根际真菌青霉 Penicillium herquei YNJ-35 中分离得到 14 个化合物，包括一个新的多环芳烃代谢产物 ent-herqueidiketal（1）和一个新的菲醌衍生物 epi-peniciherqueinone（2），以及 12 个已知化合物 3-14。通过波谱数据或单晶 X 射线衍射分析或旋光值确定了 1-14 的结构和 1 和 2 的绝对构型。化合物 1 对金黄色葡萄球菌（ATCC 29213）具有很强的抗菌活性，最小抑菌浓度（MIC）为 8μg/mL。在细胞毒性测定中，化合物 1 对乳腺癌 MCF-7 和小鼠小胶质细胞 BV2 细胞的抑制活性较弱，半数最大抑制浓度（IC ）分别为 17.58 和 29.56μM；化合物 14 对 BV2 和 MCF-7 细胞的细胞毒性更强，IC 值分别为 6.57 和 10.26μM。
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