海洋海绵来源真菌 sp. SCSIO41015 的新生物碱和聚酮化合物。
New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus sp. SCSIO41015.
机构信息
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
出版信息
Mar Drugs. 2019 Jul 5;17(7):398. doi: 10.3390/md17070398.
The sponge-derived fungus sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (-), including two new alkaloids ( and ) and one new pyrone derivative (). Their structures were elucidated by analysis of 1D/2D NMR data and HR-ESI-MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC value of 5.19 μM. Compounds and showed weak antibacterial activity against and respectively, both with MIC values of 57 μg/mL. Furthermore, compound displayed potent antibacterial activity against with an MIC value of 3.75 μg/mL.
从固体大米培养基中培养的海绵来源真菌 sp. SCSIO41015 产生了二十一种化合物（-），包括两种新的生物碱（和）和一种新的吡喃酮衍生物（）。通过分析 1D/2D NMR 数据和 HR-ESI-MS，确定了它们的结构。通过单晶 X 射线衍射分析和与报道的比旋光度的比较，确定了它们的绝对构型。化合物对人胃癌细胞 MGC803 表现出选择性细胞毒性，IC 值为 5.19 μM。化合物和对和的抑菌活性较弱，MIC 值均为 57 μg/mL。此外，化合物对的抑菌活性较强，MIC 值为 3.75 μg/mL。
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