Tourniaire J, Mazenod B, Corniau J, Fevre M
Ann Endocrinol (Paris). 1979 Jan-Feb;40(1):71-2.
18 patients suffering from idiopathic hemochromatosis were studied. Plasma testosterone was stimulated by HCG. Basal plasma LH and FSH were significantly lower for the male group compared to healthy men. Lack of reponse of plasma LH and FSH after IV LHRH (100 microgram) was observed in 10 cases; among the patients with a normal response there were a postmenopausal woman, a 47 XXY syndrome, and the two youngest patients. Repeated infusions of LHRH (200 microgram/day x 5 d) did not increase LH in 8 out of 9 cases. Repeated plasma LH determination for 4 hours showed no pulsatile pattern in 6/7 patients. Plasma LH-RH measured in 7 cases was not elevated. The conclusion is that hypogonadism in hemochromatosis, when present, is related to a gonadotropin secretion defect, presumably of pituitary origin.
对18例特发性血色素沉着症患者进行了研究。通过人绒毛膜促性腺激素（HCG）刺激血浆睾酮。与健康男性相比，男性组的基础血浆促黄体生成素（LH）和促卵泡生成素（FSH）显著降低。10例患者静脉注射促性腺激素释放激素（LHRH，100微克）后，血浆LH和FSH无反应；在反应正常的患者中有一名绝经后女性、一名47 XXY综合征患者以及两名最年轻的患者。9例患者中有8例重复输注LHRH（200微克/天×5天）后LH未升高。7例患者中有6例在4小时内重复测定血浆LH未显示出脉冲模式。7例患者测定的血浆促性腺激素释放激素（LH-RH）未升高。结论是，血色素沉着症患者若存在性腺功能减退，与促性腺激素分泌缺陷有关，推测起源于垂体。
