Department of Psychology, Royal Holloway University of London, London, UK.
Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
AIDS Behav. 2024 Jan;28(1):274-284. doi: 10.1007/s10461-023-04151-8. Epub 2023 Aug 14.
Oral PrEP's effectiveness relies on adequate adherence during periods of substantial HIV risk. Since most PrEP users will miss doses, understanding predictors within participants can help to explain adherence. We used a cross-sectional, within-participant design with 67 gay, bisexual, and other men who have sex with men taking PrEP daily. Using a questionnaire, informed by the Information Motivation Behavioral Skills Model, participants were asked about an adherent and a non-adherent episode. PrEP non-adherence was associated with non-normality of the day (p < .001), being out of the home (p < .001), weekend days (p = .01), having company (p = .02), using substances (p = 0.02), not using reminders (p = .03), lower PrEP information (p = .04), lower behavioural skills (p < .001) and less positive affect (p = .002). PrEP adherence assessment could focus on situational variations, supporting the construction of alternative strategies to facilitate adherence in these situations.
口服暴露前预防（PrEP）的有效性依赖于在大量 HIV 风险期间的充分依从性。由于大多数 PrEP 用户会漏服药物，因此了解参与者中的预测因素有助于解释依从性。我们使用了一项横断面、参与者内设计，纳入了 67 名每日服用 PrEP 的男同性恋、双性恋和其他与男性发生性关系的男性。参与者使用了一份基于信息动机行为技能模型的问卷，被问及一个依从性和一个不依从性的事件。PrEP 不依从与日常非正态性（p<0.001）、不在家（p<0.001）、周末（p=0.01）、有同伴（p=0.02）、使用物质（p=0.02）、不使用提醒（p=0.03）、PrEP 信息较低（p=0.04）、行为技能较低（p<0.001）和积极情绪较低（p=0.002）相关。PrEP 依从性评估可以关注情境变化，支持制定替代策略，以促进这些情况下的依从性。
