走向 T 细胞耗竭的岔路。
The road not taken en route to T cell exhaustion.
机构信息
La Jolla Institute for Immunology, La Jolla, CA, USA.
Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.
出版信息
Nat Immunol. 2023 Sep;24(9):1402-1404. doi: 10.1038/s41590-023-01596-w.
Abstract
The first detailed investigation of CD8 tumor-infiltrating T cell differentiation in the hours after cells enter a tumor has yielded an unexpected twist. Naive T cells veer away from effector fate and enter the path towards exhaustion much earlier than expected.
摘要
对细胞进入肿瘤后数小时内 CD8 肿瘤浸润 T 细胞分化的首次详细研究出现了一个意外的转折。幼稚 T 细胞偏离效应器命运，进入衰竭途径的时间比预期的要早得多。
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