Farzana Sadaf -, Sidra Siddiqui -, Sarah Jameel Khan -
Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.
Pak J Pharm Sci. 2023 May;36(3):783-787.
Pistacia lentiscus L (PL) is commonly known as gum mastic. Its powder and tears are widely used in herbal/ medicinal item, cosmetics and food supplements. The oil and gum resin of (PL) are anticipated to be consuming with other pharmacological agents in order to avoid any drug- drug interaction. The study was design to evaluate the sub-acute toxicity of gum mastic powder (GMP) and gum mastic tears (GMT) at the dose of 0.2857g/kg for a duration of 14 days. On 14th day of experiment, different biochemical test was performed on animal blood sample and then sacrificed for histopathological analysis of heart, liver and kidney and spleen. There were no significant differences in the gross and histopathology changes in vital organs like heart, liver and kidney and spleen tissues at the dose of 0.2857g/kg of gum mastic tears and powder and their corresponding control. The results indicate that both GMP and GMT can be used as cardio-protective and in gout treatment. It was concluded that use of gum mastic tears and powdered was found to be safe and consequently use in the pharmaceutical and cosmetic industries.
乳香黄连木（Pistacia lentiscus L，PL）俗称乳香。其粉末和泪滴状树脂广泛用于草药/药品、化妆品和食品补充剂中。预计乳香黄连木的油和胶树脂会与其他药物制剂一起使用，以避免任何药物相互作用。本研究旨在评估乳香粉末（GMP）和乳香泪滴状树脂（GMT）在剂量为0.2857g/kg时，持续14天的亚急性毒性。在实验的第14天，对动物血液样本进行了不同的生化测试，然后处死动物，对心脏、肝脏、肾脏和脾脏进行组织病理学分析。在剂量为0.2857g/kg的乳香泪滴状树脂和粉末及其相应对照组中，心脏、肝脏、肾脏和脾脏等重要器官的大体和组织病理学变化没有显著差异。结果表明，GMP和GMT均可用于心脏保护和痛风治疗。得出的结论是，发现使用乳香泪滴状树脂和粉末是安全的，因此可用于制药和化妆品行业。
