Mellerup E T, Plenge P
Eur J Pharmacol. 1986 Jul 15;126(1-2):155-8. doi: 10.1016/0014-2999(86)90753-3.
A single dose of 50 mg chlorimipramine was followed by a rapid and pronounced decrease in [3H]imipramine binding to platelet membranes. Incubation of human platelets or platelet membranes with 25 nM chlorimipramine similarly reduced [3H]imipramine binding. Imipramine, desmethylchlorimipramine, chlorpromazine and some serotonin uptake inhibitors did not have this effect. The effect was not due to chlorimipramine remaining in the membranes during the binding analysis.
单次服用50毫克氯米帕明后，[3H] 丙咪嗪与血小板膜的结合迅速且显著减少。用25纳摩尔氯米帕明孵育人血小板或血小板膜同样会降低[3H] 丙咪嗪的结合。丙咪嗪、去甲氯米帕明、氯丙嗪和一些5-羟色胺摄取抑制剂没有这种作用。这种作用并非由于在结合分析过程中氯米帕明残留在膜中所致。
