Further evidence for the effect of pinacolyl dimethylphosphinate on soman storage in muscle tissue.

Diaphragms isolated from rats 60 or 120 min after the intravenous injection of 6 X LD50 soman were incubated with electric eel acetylcholinesterase. As calculated from the enzyme inhibition, detectable amounts of P(-)-soman (1,2-dimethylpropyl methylphosphonofluoridate) were released from the diaphragm into the medium even 120 min post-injection. This release was reduced by additional pretreatment of the rats with pinacolyl dimethylphosphinate, providing further evidence that this compound prevents the storage of soman in diaphragm tissue.