Obach R, Menargues A, Vallès J, Vallès J M, García-Sevilla J A
Eur J Pharmacol. 1986 Aug 15;127(3):225-31. doi: 10.1016/0014-2999(86)90368-7.
Cyanamide, a disulfiram-like drug used in the treatment of alcoholism, decreased in a dose-dependent manner (2-25 mg/kg) the body weight gain curve in rats, which resulted in a marked decrease of body weight (10-35%). Long-term administration of cyanamide also decreased food intake (6-34%) in a dose-dependent manner (2-25 mg/kg). Both effects of cyanamide were reversible. After the acute and long-term administration (1-12 months) of cyanamide (8-35 mg/kg) the brain concentration of 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MOPEG-SO4) was also significantly increased (26-46%). Cyanamide, however, had no effects on the brain concentration of noradrenaline, dopamine, 5-hydroxytryptamine, tryptophan and 5-hydroxyindolacetic acid. It is suggested that the loss of weight, the decrease in food intake and the increase in brain MOPEG-SO4 induced by cyanamide reflect possible anorectic properties of the drug.
氰胺是一种用于治疗酒精中毒的双硫仑样药物，它以剂量依赖方式（2 - 25毫克/千克）降低大鼠的体重增加曲线，导致体重显著下降（10 - 35%）。长期给予氰胺也以剂量依赖方式（2 - 25毫克/千克）减少食物摄入量（6 - 34%）。氰胺的这两种作用都是可逆的。在急性和长期给予（1 - 12个月）氰胺（8 - 35毫克/千克）后，3 - 甲氧基 - 4 - 羟基苯乙二醇硫酸盐（MOPEG - SO4）的脑浓度也显著增加（26 - 46%）。然而，氰胺对去甲肾上腺素、多巴胺、5 - 羟色胺、色氨酸和5 - 羟吲哚乙酸的脑浓度没有影响。有人认为，氰胺引起的体重减轻、食物摄入量减少和脑MOPEG - SO4增加反映了该药物可能具有的食欲抑制特性。
