Schumann W, Hillesheim H G, Gira G
Exp Clin Endocrinol. 1986 Jul;87(2):118-24. doi: 10.1055/s-0029-1210532.
A number of drugs including steroid hormones undergo enterohepatic circulation (EHC) which influences the drug disposition parameters. EHC of drugs leads to prolonged drug exposition which may enhance the risk of liver incompatibility. The extent of EHC expressed by the reabsorption rate of a given drug is of interest from the clinical and toxicological point of view. A two-compartment model with an additional time lag was realized by a hybrid computer system to study the influence of EHC on the shape of plasma concentration-time profiles and pharmacokinetic parameters. Reabsorption rates of potential steroid drugs were calculated by model-simulation and the results compared with the experimentally found ones. Although the lag time model is only a simplified approximation to the underlying physiological processes it reflects sufficiently the pharmacokinetic profile of steroid drugs subject to EHC.
包括甾体激素在内的多种药物会经历肠肝循环（EHC），这会影响药物处置参数。药物的肠肝循环会导致药物暴露时间延长，这可能会增加肝脏不相容性的风险。从临床和毒理学角度来看，用特定药物的重吸收率表示的肠肝循环程度是令人感兴趣的。通过混合计算机系统实现了一个具有额外时间滞后的二室模型，以研究肠肝循环对血药浓度-时间曲线形状和药代动力学参数的影响。通过模型模拟计算了潜在甾体药物的重吸收率，并将结果与实验结果进行了比较。尽管滞后时间模型只是对潜在生理过程的一种简化近似，但它充分反映了受肠肝循环影响的甾体药物的药代动力学特征。
