Córdova Ezequiel, Mykietiuk Analia, De Vedia Lautaro, Bacelar Brenda, Cáceres María Florencia, Nemirovsky Corina, Contreras Rosa, Alzogaray Maria Fernanda, Nannini Esteban, Consalvo María Fernanda, Soler Puy Lucrecia, Scapellato Pablo G, Barcelona Laura, Golikow Mariana L, Piñeiro María Florencia, Miño Hugo J, Cabral Myrna, Lamponi Tappata Lucía, Lopardo Gustavo, Sued Omar, Stryjewski Martín E
Hospital Cosme Argerich, Buenos Aires, Argentina. E-mail:
Instituto Médico Platense, La Plata, Buenos Aires, Argentina.
Medicina (B Aires). 2023;83(4):551-557.
Clinical features and outcomes of SARSCoV-2 infections may change between different waves of the pandemic. The objective of this study was to compare clinical characteristics and outcomes between two cohorts of patients hospitalized for COVID-19 during the first and second waves in Argentina.
Multicenter and prospective registry of patients =18 years old with a confirmed diagnosis of COVID-19 admitted to 18 hospitals in Argentina during the first wave (March to October 2020) and second wave (March to July 2021) of the pandemic. Demographics, clinical characteristics, and outcomes of these patients were compared.
A total of 1691 patients were included (first wave n = 809, second wave n = 882). Hospitalized patients during the second wave were older (median 53 years vs. 61 years, p < 0.001), had more comorbidities (71% vs. 77%, p=0.007) and required more supplemental oxygen at admission (21% vs 62%, p < 0.001). During hospitalization, patients of the second wave required more supplemental oxygen (49% vs. 85%, p < 0.001), invasive ventilation (12% vs. 22%, p < 0.001) and had higher 30- day mortality (11% vs. 26%, p < 0.001). Comparing only patients who required supplemental oxygen during hospitalization, 30-day mortality was 20% and 30% p < 0.001 for the first and second wave, respectively.
Compared to patients admitted during the first wave, patients admitted with SARS-CoV2 during the second wave in Argentina were more seriously ill and had a higher mortality.
在新冠大流行的不同阶段，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的临床特征和结果可能会有所变化。本研究的目的是比较阿根廷第一波（2020年3月至10月）和第二波（2021年3月至7月）新冠疫情期间因COVID-19住院的两组患者的临床特征和结果。
对年龄≥18岁、确诊为COVID-19的患者进行多中心前瞻性登记，这些患者在阿根廷大流行的第一波（2020年3月至10月）和第二波（2021年3月至7月）期间入住18家医院。比较了这些患者的人口统计学、临床特征和结果。
共纳入1691例患者（第一波809例，第二波882例）。第二波住院患者年龄更大（中位数53岁对61岁，p<0.001），合并症更多（71%对77%，p=0.007），入院时需要更多补充氧气（21%对62%，p<0.001）。住院期间，第二波患者需要更多补充氧气（49%对85%，p<0.001）、有创通气（12%对22%，p<0.001），且30天死亡率更高（11%对26%，p<0.001）。仅比较住院期间需要补充氧气的患者，第一波和第二波的30天死亡率分别为20%和30%，p<0.001。
与第一波入院患者相比，阿根廷第二波因SARS-CoV-2入院的患者病情更严重，死亡率更高。
