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肝硬化患者的第三梭状芽孢杆菌菌血症

[Clostridium tertium bacteremia in patient with liver cirrhosis].

作者信息

Lamberto Yesica, Huarachi-Chirilla Yaneth, Dominguez Cecilia, Saul Pablo, Chediack Viviana, Cunto Eleonora

机构信息

Departamento de Terapia Intensiva-DAIPIC, Hospital de Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina. E-mail:

Departamento de Terapia Intensiva-DAIPIC, Hospital de Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina.

出版信息

Medicina (B Aires). 2023;83(4):635-638.

PMID:37582140
Abstract

Clostridium tertium is a bacterium of the Clostridiaceae family which can be found colonizing the gastrointestinal tract. Unlike other members of its family, it does not produce exotoxins. It was described for the first time in 1917 and in 1963 it was established as a pathogen in humans. Since then, cases have been reported mainly in immunosuppressed hosts, predominantly with primary focus at the abdominal level. The case of a 48-year-old man with a history of cirrhosis and hepatitis C virus infection is described. He presented an obstructed umbilical hernia that required intestinal resection and anastomosis, with positive blood and abdominal fluid cultures for Clostridium tertium. This case is of clinical importance due to the low prevalence of this germ, the possibility of resistance to usual antibiotic regimens and its sub diagnostic given the morphological and growth similarities with Bacillus or Lactobacillus.

摘要

第三梭菌是梭菌科的一种细菌,可在胃肠道中定殖。与该科的其他成员不同,它不产生外毒素。它于1917年首次被描述,并于1963年被确认为人类病原体。从那时起,病例主要在免疫抑制宿主中被报道,主要集中在腹部。本文描述了一名48岁有肝硬化和丙型肝炎病毒感染史男性的病例。他出现了梗阻性脐疝,需要进行肠切除和吻合术,血液和腹腔积液培养出第三梭菌呈阳性。由于这种细菌的低流行率、对常用抗生素方案耐药的可能性以及鉴于其与芽孢杆菌或乳酸杆菌在形态和生长上的相似性而难以诊断,该病例具有临床重要性。

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