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CC16: A Treatable Trait in Asthma?

作者信息

Bloom Chloe I, Adcock Ian M

机构信息

National Heart and Lung Institute Imperial College London London, United Kingdom.

出版信息

Am J Respir Crit Care Med. 2023 Oct 1;208(7):745-746. doi: 10.1164/rccm.202307-1255ED.

DOI:10.1164/rccm.202307-1255ED
PMID:37582203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10563192/
Abstract
摘要

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1
CC16: A Treatable Trait in Asthma?CC16:哮喘的一个可治疗特征?
Am J Respir Crit Care Med. 2023 Oct 1;208(7):745-746. doi: 10.1164/rccm.202307-1255ED.
2
A polymorphism of the CC16 gene is associated with an increased risk of asthma.CC16基因的多态性与哮喘风险增加相关。
J Med Genet. 1998 Jun;35(6):463-7. doi: 10.1136/jmg.35.6.463.
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Association between plasma CC16 levels, the A38G polymorphism, and asthma.血浆CC16水平、A38G多态性与哮喘之间的关联。
Am J Respir Crit Care Med. 2000 Jan;161(1):124-7. doi: 10.1164/ajrccm.161.1.9904073.
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Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children.克拉拉细胞蛋白16(CC16)基因多态性影响哮喘儿童气道反应性的程度。
J Allergy Clin Immunol. 2003 Mar;111(3):515-9. doi: 10.1067/mai.2003.180.
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Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition.克拉拉细胞16千道尔顿蛋白通过依赖HMGB1介导的信号抑制方式调节气道上皮细胞凋亡,减轻屋尘螨诱导的气道炎症和损伤。
Mol Med. 2021 Feb 4;27(1):11. doi: 10.1186/s10020-021-00277-4.
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Association of urine CC16 and lung function and asthma in Chinese children.中国儿童尿CC16与肺功能及哮喘的关联
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Acute asthma in children: Relationships among CD14 and CC16 genotypes, plasma levels, and severity.儿童急性哮喘:CD14和CC16基因型、血浆水平与严重程度之间的关系。
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Effects of obesity on CC16 and their potential role in overweight/obese asthma.肥胖对 CC16 的影响及其在超重/肥胖型哮喘中的潜在作用。
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An association study between the Clara cell secretory protein CC16 A38G polymorphism and asthma phenotypes.克拉拉细胞分泌蛋白CC16 A38G多态性与哮喘表型之间的关联研究。
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Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes.丹麦年轻成年人未选择人群中哮喘相关表型与CC16 A38G多态性之间的关联。
Immunogenetics. 2005 Apr;57(1-2):25-32. doi: 10.1007/s00251-005-0778-2. Epub 2005 Mar 3.

本文引用的文献

1
Circulating CC16 and Asthma: A Population-based, Multicohort Study from Early Childhood through Adult Life.循环 CC16 和哮喘:一项从儿童早期到成年的基于人群的多队列研究。
Am J Respir Crit Care Med. 2023 Oct 1;208(7):758-769. doi: 10.1164/rccm.202301-0041OC.
2
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.支气管上皮细胞中低 CC16mRNA 表达水平与哮喘严重程度相关。
Am J Respir Crit Care Med. 2023 Feb 15;207(4):438-451. doi: 10.1164/rccm.202206-1230OC.
3
Club cell secretory protein and lung function in children with cystic fibrosis.囊泡细胞分泌蛋白与囊性纤维化患儿的肺功能。
J Cyst Fibros. 2022 Sep;21(5):811-820. doi: 10.1016/j.jcf.2022.03.007. Epub 2022 Mar 31.
4
Predicting the course of asthma from childhood until early adulthood.预测哮喘从儿童期到成年早期的病程。
Curr Opin Allergy Clin Immunol. 2022 Apr 1;22(2):115-122. doi: 10.1097/ACI.0000000000000810.
5
Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.CC-16 对 COPD 风险和进展的保护作用:一项孟德尔随机研究。
Thorax. 2020 Nov;75(11):934-943. doi: 10.1136/thoraxjnl-2019-214487. Epub 2020 Aug 24.
6
Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.肺泡细胞蛋白分泌缺陷导致肺功能改变。
Am J Respir Crit Care Med. 2019 Feb 1;199(3):302-312. doi: 10.1164/rccm.201807-1345OC.
7
Asthma transition from childhood into adulthood.哮喘从儿童期向成年期的转变。
Lancet Respir Med. 2017 Mar;5(3):224-234. doi: 10.1016/S2213-2600(16)30187-4. Epub 2016 Sep 22.
8
Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study.循环 CC16 浓度与肺功能及全生命周期慢性阻塞性肺疾病发展的关系:一项前瞻性研究。
Lancet Respir Med. 2015 Aug;3(8):613-20. doi: 10.1016/S2213-2600(15)00196-4. Epub 2015 Jul 6.
9
Protective role for club cell secretory protein-16 (CC16) in the development of COPD.克拉拉细胞分泌蛋白-16(CC16)在慢性阻塞性肺疾病(COPD)发展中的保护作用。
Eur Respir J. 2015 Jun;45(6):1544-56. doi: 10.1183/09031936.00134214. Epub 2015 Feb 19.
10
The CC16 A38G polymorphism is associated with asymptomatic airway hyper-responsiveness and development of late-onset asthma.CC16 A38G 多态性与无症状气道高反应性和迟发性哮喘的发展有关。
Ann Allergy Asthma Immunol. 2013 Nov;111(5):376-381.e1. doi: 10.1016/j.anai.2013.08.005. Epub 2013 Aug 30.