Kantar Rami S, Hamdan Usama S, Muller John N, Hemal Kshipra, Younan Robert A, Haddad Mario, Melhem Antonio M, Don Griot J Peter W, Breugem Corstiaan C, Mokdad Ali H
Global Smile Foundation, Norwood, MA.
Department of Plastic Surgery, The Hansjorg Wyss, NYU Langone Health, New York City, NY.
J Craniofac Surg. 2023 Oct 1;34(7):2012-2015. doi: 10.1097/SCS.0000000000009591. Epub 2023 Aug 15.
Orofacial clefts, in particular cleft lip and cleft palate, are among the most common congenital anomalies. Despite guidelines recommending early surgical correction, a global backlog of untreated patients persists. This has made orofacial clefts an attractive target for global cleft care initiatives. The most recent global burden of orofacial clefts was estimated to be 529,758.92 disability-adjusted life years (95% uncertainty interval: 362,492.88-798,419.69 disability-adjusted life years), whereas the global prevalence of orofacial clefts was estimated to be 4.6 million (95% uncertainty interval: 3.8-5.7 million). An inverse relationship exists between the Sociodemographic Index and the burden of orofacial clefts. Sub-Saharan Africa, Middle East/North Africa, and South Asia are the regions carrying the most significant burden of orofacial clefts. This manuscript provides updated estimates of the global burden and prevalence of orofacial clefts, acting as a guide to direct future investments, resources, and initiatives from individuals and organizations engaged in global cleft care delivery with the goal of building sustainable cleft care capacity where it is needed the most.
口面部裂隙，尤其是唇裂和腭裂，是最常见的先天性畸形之一。尽管有指南推荐早期手术矫正，但全球仍存在未经治疗患者的积压情况。这使得口面部裂隙成为全球腭裂护理倡议的一个有吸引力的目标。据估计，口面部裂隙的最新全球负担为529,758.92伤残调整生命年（95%不确定区间：362,492.88 - 798,419.69伤残调整生命年），而口面部裂隙的全球患病率估计为460万（95%不确定区间：380万 - 570万）。社会人口学指数与口面部裂隙负担之间存在反比关系。撒哈拉以南非洲、中东/北非和南亚是口面部裂隙负担最重的地区。本手稿提供了口面部裂隙全球负担和患病率的最新估计，为从事全球腭裂护理的个人和组织指导未来投资、资源和倡议提供参考，目标是在最需要的地方建立可持续的腭裂护理能力。
