Turku University Hospital and University of Turku, Turku, Finland.
University of Helsinki, Helsinki, Finland.
Diabetes Res Clin Pract. 2023 Sep;203:110875. doi: 10.1016/j.diabres.2023.110875. Epub 2023 Aug 13.
We assessed the temporal trends in the prevalence of diabetes and in its associations with outcomes among patients with atrial fibrillation (AF).
The registry-based FinACAF study covered all patients with incident AF in Finland between 2007 and 2018. Ischemic stroke (IS) and mortality rates were computed using Poisson regression model.
We identified 229565 patients (50.0% female; mean age 72.7 years; mean follow-up 4.0 years) patients with incident AF. The prevalence of diabetes increased steadily from 15.5% in 2007 to 26.3% in 2018. A decrease in IS and mortality rates was observed during the study period both in patients with and without diabetes. Diabetes was associated with IS and mortality (adjusted incidence rate ratios with 95% confidence intervals 1.22 (1.17-1.26) and 1.32 (1.29-1.34), respectively). The impact of diabetes on IS risk remained stable, while its effect on mortality increased slightly during the observation period.
The prevalence of diabetes has increased considerably among patients with AF between 2007 and 2018. There have been substantial improvements in the prognosis of AF patients with diabetes. However, diabetes remains a significant risk factor for IS and mortality in this patient population.
我们评估了糖尿病在心房颤动（AF）患者中的患病率及其与结局的相关性的时间趋势。
基于注册的 FinACAF 研究涵盖了 2007 年至 2018 年期间芬兰所有新发 AF 患者。使用泊松回归模型计算缺血性中风（IS）和死亡率。
我们确定了 229565 名（50.0%为女性；平均年龄 72.7 岁；平均随访 4.0 年）新发 AF 患者。糖尿病的患病率从 2007 年的 15.5%稳步上升至 2018 年的 26.3%。在研究期间，无论是否患有糖尿病，IS 和死亡率均呈下降趋势。糖尿病与 IS 和死亡率相关（调整后的发病率比，95%置信区间分别为 1.22（1.17-1.26）和 1.32（1.29-1.34））。糖尿病对 IS 风险的影响保持稳定，而其对死亡率的影响在观察期间略有增加。
2007 年至 2018 年期间，AF 患者中糖尿病的患病率显著增加。糖尿病患者的 AF 预后有了显著改善。然而，糖尿病仍然是该患者人群中 IS 和死亡率的重要危险因素。
