Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Hepato‑Pancreatic‑Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Mol Cancer. 2023 Aug 15;22(1):137. doi: 10.1186/s12943-023-01841-8.
Glycolytic reprogramming is one of the most important features of cancer and plays an integral role in the progression of cancer. In cancer cells, changes in glucose metabolism meet the needs of self-proliferation, angiogenesis and lymphangiogenesis, metastasis, and also affect the immune escape, prognosis evaluation and therapeutic effect of cancer. The n6-methyladenosine (m6A) modification of RNA is widespread in eukaryotic cells. Dynamic and reversible m6A modifications are widely involved in the regulation of cancer stem cell renewal and differentiation, tumor therapy resistance, tumor microenvironment, tumor immune escape, and tumor metabolism. Lately, more and more evidences show that m6A modification can affect the glycolysis process of tumors in a variety of ways to regulate the biological behavior of tumors. In this review, we discussed the role of glycolysis in tumor genesis and development, and elaborated in detail the profound impact of m6A modification on different tumor by regulating glycolysis. We believe that m6A modified glycolysis has great significance and potential for tumor treatment.
糖酵解重编程是癌症的最重要特征之一，在癌症的进展中起着重要作用。在癌细胞中，葡萄糖代谢的变化满足了自我增殖、血管生成和淋巴管生成、转移的需求，还影响了癌症的免疫逃逸、预后评估和治疗效果。RNA 的 N6-甲基腺苷（m6A）修饰广泛存在于真核细胞中。动态和可逆的 m6A 修饰广泛参与调节癌症干细胞更新和分化、肿瘤治疗耐药性、肿瘤微环境、肿瘤免疫逃逸和肿瘤代谢。最近，越来越多的证据表明，m6A 修饰可以通过多种方式影响肿瘤的糖酵解过程，从而调节肿瘤的生物学行为。在这篇综述中，我们讨论了糖酵解在肿瘤发生和发展中的作用，并详细阐述了 m6A 修饰通过调节糖酵解对不同肿瘤的深刻影响。我们相信 m6A 修饰的糖酵解对肿瘤治疗具有重要意义和潜力。
